G-quadruplex inducer/stabilizer pyridostatin targets SUB1 to promote cytotoxicity of a transplatinum complex

Pyridostatin (PDS) is a well-known G-quadruplex (G4) inducer and stabilizer, yet its target genes have remained unclear. Herein, applying MS proteomics strategy, we revealed PDS significantly downregulated 22 proteins but upregulated 16 proteins in HeLa cancer cells, of which the genes both contain...

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Detalles Bibliográficos
Autores principales: Hou, Yinzhu, Gan, Tieliang, Fang, Tiantian, Zhao, Yao, Luo, Qun, Liu, Xingkai, Qi, Luyu, Zhang, Yanyan, Jia, Feifei, Han, Juanjuan, Li, Shumu, Wang, Shijun, Wang, Fuyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8989551/
https://www.ncbi.nlm.nih.gov/pubmed/35258624
http://dx.doi.org/10.1093/nar/gkac151

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