Type I Interferon Transcriptional Network Regulates Expression of Coinhibitory Receptors in Human T cells

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While inhibition of T cell co-inhibitory receptors has revolutionized cancer therapy, the mechanisms governing their expression on human T cells have not been elucidated. Here we show that type 1 interferon (IFN-I) regulates co-inhibitory receptor expression on human T cells, inducing PD-1/TIM-3/LAG...

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Detalles Bibliográficos
Autores principales: Sumida, Tomokazu S., Dulberg, Shai, Schupp, Jonas C., Lincoln, Matthew R., Stillwell, Helen A., Axisa, Pierre-Paul, Comi, Michela, Unterman, Avraham, Kaminski, Naftali, Madi, Asaf, Kuchroo, Vijay K., Hafler, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8989655/
https://www.ncbi.nlm.nih.gov/pubmed/35301508
http://dx.doi.org/10.1038/s41590-022-01152-y

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