Bcl-xL acts as an inhibitor of IP(3)R channels, thereby antagonizing Ca(2+)-driven apoptosis

Anti-apoptotic Bcl-2-family members not only act at mitochondria but also at the endoplasmic reticulum, where they impact Ca(2+) dynamics by controlling IP(3) receptor (IP(3)R) function. Current models propose distinct roles for Bcl-2 vs. Bcl-xL, with Bcl-2 inhibiting IP(3)Rs and preventing pro-apop...

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Detalles Bibliográficos
Autores principales: Rosa, Nicolas, Ivanova, Hristina, Wagner, Larry E., Kale, Justin, La Rovere, Rita, Welkenhuyzen, Kirsten, Louros, Nikolaos, Karamanou, Spyridoula, Shabardina, Victoria, Lemmens, Irma, Vandermarliere, Elien, Hamada, Kozo, Ando, Hideaki, Rousseau, Frederic, Schymkowitz, Joost, Tavernier, Jan, Mikoshiba, Katsuhiko, Economou, Anastassios, Andrews, David W., Parys, Jan B., Yule, David I., Bultynck, Geert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8990011/
https://www.ncbi.nlm.nih.gov/pubmed/34750538
http://dx.doi.org/10.1038/s41418-021-00894-w

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