An atlas of inter- and intra-tumor heterogeneity of apoptosis competency in colorectal cancer tissue at single-cell resolution

Cancer cells’ ability to inhibit apoptosis is key to malignant transformation and limits response to therapy. Here, we performed multiplexed immunofluorescence analysis on tissue microarrays with 373 cores from 168 patients, segmentation of 2.4 million individual cells, and quantification of 18 cell...

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Detalles Bibliográficos
Autores principales: Lindner, Andreas Ulrich, Salvucci, Manuela, McDonough, Elizabeth, Cho, Sanghee, Stachtea, Xanthi, O’Connell, Emer P., Corwin, Alex D., Santamaria-Pang, Alberto, Carberry, Steven, Fichtner, Michael, Van Schaeybroeck, Sandra, Laurent-Puig, Pierre, Burke, John P., McNamara, Deborah A., Lawler, Mark, Sood, Anup, Graf, John F., Rehm, Markus, Dunne, Philip D., Longley, Daniel B., Ginty, Fiona, Prehn, Jochen H. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8990071/
https://www.ncbi.nlm.nih.gov/pubmed/34754079
http://dx.doi.org/10.1038/s41418-021-00895-9

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