Spontaneous activity of the mitochondrial apoptosis pathway drives chromosomal defects, the appearance of micronuclei and cancer metastasis through the Caspase-Activated DNAse

Micronuclei are DNA-containing structures separate from the nucleus found in cancer cells. Micronuclei are recognized by the immune sensor axis cGAS/STING, driving cancer metastasis. The mitochondrial apoptosis apparatus can be experimentally triggered to a non-apoptotic level, and this can drive th...

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Detalles Bibliográficos
Autores principales: Haimovici, Aladin, Höfer, Christoph, Badr, Mohamed Tarek, Bavafaye Haghighi, Elham, Amer, Tarek, Boerries, Melanie, Bronsert, Peter, Glavynskyi, Ievgen, Fanfone, Deborah, Ichim, Gabriel, Thilmany, Nico, Weber, Arnim, Brummer, Tilman, Spohr, Corinna, Öllinger, Rupert, Janssen, Klaus-Peter, Rad, Roland, Häcker, Georg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8990075/
https://www.ncbi.nlm.nih.gov/pubmed/35393399
http://dx.doi.org/10.1038/s41419-022-04768-y

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