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Lipid Homeostasis and Its Links With Protein Misfolding Diseases
The maintenance of lipid homeostasis is essential for the normal functioning of living organisms. Alterations of the lipid homeostasis system remodel the composition of the lipidome, potentially leading to the formation of toxic lipid species. In turn, lipidome changes can affect the protein homeost...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8990168/ https://www.ncbi.nlm.nih.gov/pubmed/35401104 http://dx.doi.org/10.3389/fnmol.2022.829291 |
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author | Vendruscolo, Michele |
author_facet | Vendruscolo, Michele |
author_sort | Vendruscolo, Michele |
collection | PubMed |
description | The maintenance of lipid homeostasis is essential for the normal functioning of living organisms. Alterations of the lipid homeostasis system remodel the composition of the lipidome, potentially leading to the formation of toxic lipid species. In turn, lipidome changes can affect the protein homeostasis system by causing perturbations that elicit protein condensation phenomena such as protein liquid-liquid phase separation and protein aggregation. Lipids can also be more directly involved the formation of aberrant condensed states of proteins by facilitating the early events that initiate these processes and by stabilizing the condensed states themselves. These observations suggest that lipid-induced toxicity can contribute to protein misfolding diseases, including Alzheimer’s and Parkinson’s diseases. According to this view, an impairment of the lipid homeostasis system generates toxic states of lipids that disturb the protein homeostasis system and promote the formation of toxic states of proteins. |
format | Online Article Text |
id | pubmed-8990168 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89901682022-04-09 Lipid Homeostasis and Its Links With Protein Misfolding Diseases Vendruscolo, Michele Front Mol Neurosci Neuroscience The maintenance of lipid homeostasis is essential for the normal functioning of living organisms. Alterations of the lipid homeostasis system remodel the composition of the lipidome, potentially leading to the formation of toxic lipid species. In turn, lipidome changes can affect the protein homeostasis system by causing perturbations that elicit protein condensation phenomena such as protein liquid-liquid phase separation and protein aggregation. Lipids can also be more directly involved the formation of aberrant condensed states of proteins by facilitating the early events that initiate these processes and by stabilizing the condensed states themselves. These observations suggest that lipid-induced toxicity can contribute to protein misfolding diseases, including Alzheimer’s and Parkinson’s diseases. According to this view, an impairment of the lipid homeostasis system generates toxic states of lipids that disturb the protein homeostasis system and promote the formation of toxic states of proteins. Frontiers Media S.A. 2022-03-25 /pmc/articles/PMC8990168/ /pubmed/35401104 http://dx.doi.org/10.3389/fnmol.2022.829291 Text en Copyright © 2022 Vendruscolo. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Vendruscolo, Michele Lipid Homeostasis and Its Links With Protein Misfolding Diseases |
title | Lipid Homeostasis and Its Links With Protein Misfolding Diseases |
title_full | Lipid Homeostasis and Its Links With Protein Misfolding Diseases |
title_fullStr | Lipid Homeostasis and Its Links With Protein Misfolding Diseases |
title_full_unstemmed | Lipid Homeostasis and Its Links With Protein Misfolding Diseases |
title_short | Lipid Homeostasis and Its Links With Protein Misfolding Diseases |
title_sort | lipid homeostasis and its links with protein misfolding diseases |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8990168/ https://www.ncbi.nlm.nih.gov/pubmed/35401104 http://dx.doi.org/10.3389/fnmol.2022.829291 |
work_keys_str_mv | AT vendruscolomichele lipidhomeostasisanditslinkswithproteinmisfoldingdiseases |