DUX4 is a multifunctional factor priming human embryonic genome activation

Double homeobox 4 (DUX4) is expressed at the early pre-implantation stage in human embryos. Here we show that induced human DUX4 expression substantially alters the chromatin accessibility of non-coding DNA and activates thousands of newly identified transcribed enhancer-like regions, preferentially...

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Detalles Bibliográficos
Autores principales: Vuoristo, Sanna, Bhagat, Shruti, Hydén-Granskog, Christel, Yoshihara, Masahito, Gawriyski, Lisa, Jouhilahti, Eeva-Mari, Ranga, Vipin, Tamirat, Mahlet, Huhtala, Mikko, Kirjanov, Ida, Nykänen, Sonja, Krjutškov, Kaarel, Damdimopoulos, Anastassius, Weltner, Jere, Hashimoto, Kosuke, Recher, Gaëlle, Ezer, Sini, Paluoja, Priit, Paloviita, Pauliina, Takegami, Yujiro, Kanemaru, Ai, Lundin, Karolina, Airenne, Tomi T., Otonkoski, Timo, Tapanainen, Juha S., Kawaji, Hideya, Murakawa, Yasuhiro, Bürglin, Thomas R., Varjosalo, Markku, Johnson, Mark S., Tuuri, Timo, Katayama, Shintaro, Kere, Juha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8990217/
https://www.ncbi.nlm.nih.gov/pubmed/35402882
http://dx.doi.org/10.1016/j.isci.2022.104137

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