The role of ubiquitination and deubiquitination in tumor invasion and metastasis

Ubiquitination is vital for multiple cellular processes via dynamic modulation of proteins related to cell growth, proliferation, and survival. Of the ubiquitination system components, E3 ubiquitin ligases and deubiquitinases have the most prominent roles in modulating tumor metastasis. This review...

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Autores principales: Han, Shuangze, Wang, Ruike, Zhang, Yangnan, Li, Xiaoying, Gan, Yu, Gao, Feng, Rong, Pengfei, Wang, Wei, Li, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8990454/
https://www.ncbi.nlm.nih.gov/pubmed/35414786
http://dx.doi.org/10.7150/ijbs.69411
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author Han, Shuangze
Wang, Ruike
Zhang, Yangnan
Li, Xiaoying
Gan, Yu
Gao, Feng
Rong, Pengfei
Wang, Wei
Li, Wei
author_facet Han, Shuangze
Wang, Ruike
Zhang, Yangnan
Li, Xiaoying
Gan, Yu
Gao, Feng
Rong, Pengfei
Wang, Wei
Li, Wei
author_sort Han, Shuangze
collection PubMed
description Ubiquitination is vital for multiple cellular processes via dynamic modulation of proteins related to cell growth, proliferation, and survival. Of the ubiquitination system components, E3 ubiquitin ligases and deubiquitinases have the most prominent roles in modulating tumor metastasis. This review will briefly summarize the observations and underlying mechanisms of multiple E3 ubiquitin ligases and deubiquitinases to regulate tumor metastasis. Further, we will discuss the relationship and importance between ubiquitination components and tumor progression.
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spelling pubmed-89904542022-04-11 The role of ubiquitination and deubiquitination in tumor invasion and metastasis Han, Shuangze Wang, Ruike Zhang, Yangnan Li, Xiaoying Gan, Yu Gao, Feng Rong, Pengfei Wang, Wei Li, Wei Int J Biol Sci Review Ubiquitination is vital for multiple cellular processes via dynamic modulation of proteins related to cell growth, proliferation, and survival. Of the ubiquitination system components, E3 ubiquitin ligases and deubiquitinases have the most prominent roles in modulating tumor metastasis. This review will briefly summarize the observations and underlying mechanisms of multiple E3 ubiquitin ligases and deubiquitinases to regulate tumor metastasis. Further, we will discuss the relationship and importance between ubiquitination components and tumor progression. Ivyspring International Publisher 2022-03-06 /pmc/articles/PMC8990454/ /pubmed/35414786 http://dx.doi.org/10.7150/ijbs.69411 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Han, Shuangze
Wang, Ruike
Zhang, Yangnan
Li, Xiaoying
Gan, Yu
Gao, Feng
Rong, Pengfei
Wang, Wei
Li, Wei
The role of ubiquitination and deubiquitination in tumor invasion and metastasis
title The role of ubiquitination and deubiquitination in tumor invasion and metastasis
title_full The role of ubiquitination and deubiquitination in tumor invasion and metastasis
title_fullStr The role of ubiquitination and deubiquitination in tumor invasion and metastasis
title_full_unstemmed The role of ubiquitination and deubiquitination in tumor invasion and metastasis
title_short The role of ubiquitination and deubiquitination in tumor invasion and metastasis
title_sort role of ubiquitination and deubiquitination in tumor invasion and metastasis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8990454/
https://www.ncbi.nlm.nih.gov/pubmed/35414786
http://dx.doi.org/10.7150/ijbs.69411
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