Mutant p53 achieved Gain-of-Function by promoting tumor growth and immune escape through PHLPP2/AKT/PD-L1 pathway

The most frequent genetic alterations of the TP53 gene in human cancer were reported. TP53 mutation gains new function as a target of genetic instability, which is associated with increased tumor progression and poor survival rate in patients. In this study, more than three hundred colorectal cancer...

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Detalles Bibliográficos
Autores principales: Liu, Nannan, Jiang, Xinxiu, Guo, Leiming, Zhang, Chuchu, Jiang, Meimei, Sun, Zhuoran, Zhang, Yizheng, Mi, Wunan, Li, Jiehan, Fu, Yang, Wang, Feng, Zhang, Lingling, Zhang, Yingjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8990467/
https://www.ncbi.nlm.nih.gov/pubmed/35414774
http://dx.doi.org/10.7150/ijbs.67200

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