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The human AP-endonuclease 1 (APE1) is a DNA G-quadruplex structure binding protein and regulates KRAS expression in pancreatic ductal adenocarcinoma cells

Pancreatic ductal adenocarcinoma (PDAC), one of the most aggressive types of cancer, is characterized by aberrant activity of oncogenic KRAS. A nuclease-hypersensitive GC-rich region in KRAS promoter can fold into a four-stranded DNA secondary structure called G-quadruplex (G4), known to regulate KR...

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Detalles Bibliográficos
Autores principales:	Pramanik, Suravi, Chen, Yingling, Song, Heyu, Khutsishvili, Irine, Marky, Luis A, Ray, Sutapa, Natarajan, Amarnath, Singh, Pankaj K, Bhakat, Kishor K
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8990529/ https://www.ncbi.nlm.nih.gov/pubmed/35286386 http://dx.doi.org/10.1093/nar/gkac172

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