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Effect of brown seaweed on plasma glucose in healthy, at-risk, and type 2 diabetic individuals: systematic review and meta-analysis
CONTEXT: Sustained hyperglycemia triggers chronic disease, including type 2 diabetes. A considerable volume of research has explored the effects of brown seaweed on plasma glucose control, but equivocal findings have been reported. OBJECTIVE: A systematic review and meta-analysis was conducted to as...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8990535/ https://www.ncbi.nlm.nih.gov/pubmed/34549293 http://dx.doi.org/10.1093/nutrit/nuab069 |
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author | Vaughan, Kate Ranawana, Viren Cooper, David Aceves-Martins, Magaly |
author_facet | Vaughan, Kate Ranawana, Viren Cooper, David Aceves-Martins, Magaly |
author_sort | Vaughan, Kate |
collection | PubMed |
description | CONTEXT: Sustained hyperglycemia triggers chronic disease, including type 2 diabetes. A considerable volume of research has explored the effects of brown seaweed on plasma glucose control, but equivocal findings have been reported. OBJECTIVE: A systematic review and meta-analysis was conducted to assess the evidence from human randomized controlled trials (RCTs) on the effects of brown seaweed on plasma glucose in healthy, at-risk, and individuals with type 2 diabetes. DATA SOURCES: MEDLINE/PubMed, EMBASE, and the Cochrane Library were searched for reports published between 2000 and 2020. DATA EXTRACTION: Population, intervention, comparator, outcome, and study design data were extracted. DATA ANALYSIS: Eighteen RCTs met our inclusion criteria. The reported results varied across and between populations. Meta-analyses showed a significant effect, favoring the intervention group for both fasting (mean difference –4.6 [95% CI –7.88, –1.33]) and postprandial (mean difference –7.1 [95% CI –7.4, –6.9]) plasma glucose. CONCLUSION: Brown seaweed and its extracts show potential for preventing and managing hyperglycemia. Our meta-analysis confirms that brown seaweed positively affects plasma glucose homeostasis, with particularly promising postprandial plasma glucose effects. However, further research is needed because no high-quality RCT was identified. Species-specific and dose–response research is also required. SYSTEMATIC REVIEW REGISTRATION: PROSPERO registration no. CRD42020187849. |
format | Online Article Text |
id | pubmed-8990535 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-89905352022-04-08 Effect of brown seaweed on plasma glucose in healthy, at-risk, and type 2 diabetic individuals: systematic review and meta-analysis Vaughan, Kate Ranawana, Viren Cooper, David Aceves-Martins, Magaly Nutr Rev Special Articles CONTEXT: Sustained hyperglycemia triggers chronic disease, including type 2 diabetes. A considerable volume of research has explored the effects of brown seaweed on plasma glucose control, but equivocal findings have been reported. OBJECTIVE: A systematic review and meta-analysis was conducted to assess the evidence from human randomized controlled trials (RCTs) on the effects of brown seaweed on plasma glucose in healthy, at-risk, and individuals with type 2 diabetes. DATA SOURCES: MEDLINE/PubMed, EMBASE, and the Cochrane Library were searched for reports published between 2000 and 2020. DATA EXTRACTION: Population, intervention, comparator, outcome, and study design data were extracted. DATA ANALYSIS: Eighteen RCTs met our inclusion criteria. The reported results varied across and between populations. Meta-analyses showed a significant effect, favoring the intervention group for both fasting (mean difference –4.6 [95% CI –7.88, –1.33]) and postprandial (mean difference –7.1 [95% CI –7.4, –6.9]) plasma glucose. CONCLUSION: Brown seaweed and its extracts show potential for preventing and managing hyperglycemia. Our meta-analysis confirms that brown seaweed positively affects plasma glucose homeostasis, with particularly promising postprandial plasma glucose effects. However, further research is needed because no high-quality RCT was identified. Species-specific and dose–response research is also required. SYSTEMATIC REVIEW REGISTRATION: PROSPERO registration no. CRD42020187849. Oxford University Press 2021-09-21 /pmc/articles/PMC8990535/ /pubmed/34549293 http://dx.doi.org/10.1093/nutrit/nuab069 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of the International Life Sciences Institute. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Special Articles Vaughan, Kate Ranawana, Viren Cooper, David Aceves-Martins, Magaly Effect of brown seaweed on plasma glucose in healthy, at-risk, and type 2 diabetic individuals: systematic review and meta-analysis |
title | Effect of brown seaweed on plasma glucose in healthy, at-risk, and type 2 diabetic individuals: systematic review and meta-analysis |
title_full | Effect of brown seaweed on plasma glucose in healthy, at-risk, and type 2 diabetic individuals: systematic review and meta-analysis |
title_fullStr | Effect of brown seaweed on plasma glucose in healthy, at-risk, and type 2 diabetic individuals: systematic review and meta-analysis |
title_full_unstemmed | Effect of brown seaweed on plasma glucose in healthy, at-risk, and type 2 diabetic individuals: systematic review and meta-analysis |
title_short | Effect of brown seaweed on plasma glucose in healthy, at-risk, and type 2 diabetic individuals: systematic review and meta-analysis |
title_sort | effect of brown seaweed on plasma glucose in healthy, at-risk, and type 2 diabetic individuals: systematic review and meta-analysis |
topic | Special Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8990535/ https://www.ncbi.nlm.nih.gov/pubmed/34549293 http://dx.doi.org/10.1093/nutrit/nuab069 |
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