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Chemical Pretreatment Activated a Plastic State Amenable to Direct Lineage Reprogramming

Somatic cells can be chemically reprogrammed into a pluripotent stem cell (CiPSC) state, mediated by an extraembryonic endoderm- (XEN-) like state. We found that the chemical cocktail applied in CiPSC generation initially activated a plastic state in mouse fibroblasts before transitioning into XEN-l...

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Detalles Bibliográficos
Autores principales:	Yang, Zhenghao, Xu, Xiaochan, Gu, Chan, Nielsen, Alexander Valentin, Chen, Guokai, Guo, Fan, Tang, Chao, Zhao, Yang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8990889/ https://www.ncbi.nlm.nih.gov/pubmed/35399519 http://dx.doi.org/10.3389/fcell.2022.865038

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