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Hyperosmolality in CHO cell culture: effects on the proteome

Chinese hamster ovary (CHO) cells are the most commonly used host cell lines for therapeutic protein production. Exposure of these cells to highly concentrated feed solution during fed-batch cultivation can lead to a non-physiological increase in osmolality (> 300 mOsm/kg) that affects cell physi...

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Detalles Bibliográficos
Autores principales:	Romanova, Nadiya, Schelletter, Louise, Hoffrogge, Raimund, Noll, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2022
Materias:	Genomics, Transcriptomics, Proteomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8990941/ https://www.ncbi.nlm.nih.gov/pubmed/35312825 http://dx.doi.org/10.1007/s00253-022-11861-x

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