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Chronic Stress Does Not Influence the Survival of Mouse Models of Glioblastoma
The existence of a clear association between stress and cancer is still a matter of debate. Recent studies suggest that chronic stress is associated with some cancer types and may influence tumor initiation and patient prognosis, but its role in brain tumors is not known. Glioblastoma (GBM) is a hig...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8990973/ https://www.ncbi.nlm.nih.gov/pubmed/35402232 http://dx.doi.org/10.3389/fonc.2022.856210 |
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author | Lopes, Marta Vieira de Castro, Joana Pojo, Marta Gonçalves, Céline S. Martins, Eduarda P. Coimbra, Bárbara Sotiropoulos, Ioannis Sousa, Nuno Rodrigues, Ana João Costa, Bruno M. |
author_facet | Lopes, Marta Vieira de Castro, Joana Pojo, Marta Gonçalves, Céline S. Martins, Eduarda P. Coimbra, Bárbara Sotiropoulos, Ioannis Sousa, Nuno Rodrigues, Ana João Costa, Bruno M. |
author_sort | Lopes, Marta |
collection | PubMed |
description | The existence of a clear association between stress and cancer is still a matter of debate. Recent studies suggest that chronic stress is associated with some cancer types and may influence tumor initiation and patient prognosis, but its role in brain tumors is not known. Glioblastoma (GBM) is a highly malignant primary brain cancer, for which effective treatments do not exist. Understanding how chronic stress, or its effector hormones glucocorticoids (GCs), may modulate GBM aggressiveness is of great importance. To address this, we used both syngeneic and xenograft in vivo orthotopic mouse models of GBM, in immunocompetent C57BL/6J or immunodeficient NSG mice, respectively, to evaluate how different paradigms of stress exposure could influence GBM aggressiveness and animals’ overall survival (OS). Our results demonstrated that a previous exposure to exogenous corticosterone administration, chronic restraint stress, or chronic unpredictable stress do not impact the OS of these mice models of GBM. Concordantly, ex vivo analyses of various GBM-relevant genes showed similar intra-tumor expression levels across all experimental groups. These findings suggest that corticosterone and chronic stress do not significantly affect GBM aggressiveness in murine models. |
format | Online Article Text |
id | pubmed-8990973 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89909732022-04-09 Chronic Stress Does Not Influence the Survival of Mouse Models of Glioblastoma Lopes, Marta Vieira de Castro, Joana Pojo, Marta Gonçalves, Céline S. Martins, Eduarda P. Coimbra, Bárbara Sotiropoulos, Ioannis Sousa, Nuno Rodrigues, Ana João Costa, Bruno M. Front Oncol Oncology The existence of a clear association between stress and cancer is still a matter of debate. Recent studies suggest that chronic stress is associated with some cancer types and may influence tumor initiation and patient prognosis, but its role in brain tumors is not known. Glioblastoma (GBM) is a highly malignant primary brain cancer, for which effective treatments do not exist. Understanding how chronic stress, or its effector hormones glucocorticoids (GCs), may modulate GBM aggressiveness is of great importance. To address this, we used both syngeneic and xenograft in vivo orthotopic mouse models of GBM, in immunocompetent C57BL/6J or immunodeficient NSG mice, respectively, to evaluate how different paradigms of stress exposure could influence GBM aggressiveness and animals’ overall survival (OS). Our results demonstrated that a previous exposure to exogenous corticosterone administration, chronic restraint stress, or chronic unpredictable stress do not impact the OS of these mice models of GBM. Concordantly, ex vivo analyses of various GBM-relevant genes showed similar intra-tumor expression levels across all experimental groups. These findings suggest that corticosterone and chronic stress do not significantly affect GBM aggressiveness in murine models. Frontiers Media S.A. 2022-03-25 /pmc/articles/PMC8990973/ /pubmed/35402232 http://dx.doi.org/10.3389/fonc.2022.856210 Text en Copyright © 2022 Lopes, Vieira de Castro, Pojo, Gonçalves, Martins, Coimbra, Sotiropoulos, Sousa, Rodrigues and Costa https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Lopes, Marta Vieira de Castro, Joana Pojo, Marta Gonçalves, Céline S. Martins, Eduarda P. Coimbra, Bárbara Sotiropoulos, Ioannis Sousa, Nuno Rodrigues, Ana João Costa, Bruno M. Chronic Stress Does Not Influence the Survival of Mouse Models of Glioblastoma |
title | Chronic Stress Does Not Influence the Survival of Mouse Models of Glioblastoma |
title_full | Chronic Stress Does Not Influence the Survival of Mouse Models of Glioblastoma |
title_fullStr | Chronic Stress Does Not Influence the Survival of Mouse Models of Glioblastoma |
title_full_unstemmed | Chronic Stress Does Not Influence the Survival of Mouse Models of Glioblastoma |
title_short | Chronic Stress Does Not Influence the Survival of Mouse Models of Glioblastoma |
title_sort | chronic stress does not influence the survival of mouse models of glioblastoma |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8990973/ https://www.ncbi.nlm.nih.gov/pubmed/35402232 http://dx.doi.org/10.3389/fonc.2022.856210 |
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