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Single Molecule Fingerprinting Reveals Different Amplification Properties of α-Synuclein Oligomers and Preformed Fibrils in Seeding Assay

[Image: see text] The quantification of α-synuclein aggregates has emerged as a promising biomarker for synucleinopathies. Assays that amplify and detect such aggregates have revealed the presence of seeding-competent species in biosamples of patients diagnosed with Parkinson’s disease. However, mul...

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Detalles Bibliográficos
Autores principales:	Lau, Derrick, Magnan, Chloé, Hill, Kathryn, Cooper, Antony, Gambin, Yann, Sierecki, Emma
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8990999/ https://www.ncbi.nlm.nih.gov/pubmed/35286811 http://dx.doi.org/10.1021/acschemneuro.1c00553

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