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Protein-Interaction Affinity Gradient Drives [4Fe–4S] Cluster Insertion in Human Lipoyl Synthase
[Image: see text] Human lipoyl synthase (LIAS) is an enzyme containing two [4Fe–4S] clusters (named FeS(RS) and FeS(aux)) involved in the biosynthesis of the lipoyl cofactor. The mechanism by which a [4Fe–4S] cluster is inserted into LIAS has thus far remained elusive. Here we show that NFU1 and ISC...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8991016/ https://www.ncbi.nlm.nih.gov/pubmed/35343688 http://dx.doi.org/10.1021/jacs.1c13626 |