Oligomerization, trans-reduction, and instability of mutant NOTCH3 in inherited vascular dementia

Cerebral small vessel disease (SVD) is a prevalent disease of aging and a major contributor to stroke and dementia. The most commonly inherited SVD, CADASIL, is caused by dominantly acting cysteine-altering mutations in NOTCH3. These mutations change the number of cysteines from an even to an odd nu...

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Detalles Bibliográficos
Autores principales: Young, Kelly Z., Rojas Ramírez, Carolina, Keep, Simon G., Gatti, John R., Lee, Soo Jung, Zhang, Xiaojie, Ivanova, Magdalena I., Ruotolo, Brandon T., Wang, Michael M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8991201/
https://www.ncbi.nlm.nih.gov/pubmed/35393494
http://dx.doi.org/10.1038/s42003-022-03259-2

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