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Expanding DNA database effectiveness

DNA databases effectively develop investigative leads, with database size being directly proportional to increased chances of solving crimes as demonstrated by a business case including a universal STR database example. DNA database size can be expanded physically by increasing the number and type o...

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Detalles Bibliográficos
Autor principal: Wickenheiser, Ray A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8991311/
https://www.ncbi.nlm.nih.gov/pubmed/35402888
http://dx.doi.org/10.1016/j.fsisyn.2022.100226
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author Wickenheiser, Ray A.
author_facet Wickenheiser, Ray A.
author_sort Wickenheiser, Ray A.
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description DNA databases effectively develop investigative leads, with database size being directly proportional to increased chances of solving crimes as demonstrated by a business case including a universal STR database example. DNA database size can be expanded physically by increasing the number and type of qualifying offenses, adding arrestees, or moving towards a universal database. The theoretical size of a DNA database can also be increased scientifically by using the inherent nature of DNA sharing by biologically related individuals by using an indirect matching strategy including Partial Matching, Familial Searching, and Investigative Genetic Genealogy (IGG). A new strategy is introduced using areas of shared DNA as a search key to locate potential relatives for further kinship evaluation. New search key strategies include Y-STR, mtDNA, and X Chromosome searching to locate potential relatives, coupled with kinship and genetic genealogical research, as well as expanded use of unidentified human remains (UHRs).
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spelling pubmed-89913112022-04-09 Expanding DNA database effectiveness Wickenheiser, Ray A. Forensic Sci Int Synerg Policy and Management (in memory of Jay Siegel) DNA databases effectively develop investigative leads, with database size being directly proportional to increased chances of solving crimes as demonstrated by a business case including a universal STR database example. DNA database size can be expanded physically by increasing the number and type of qualifying offenses, adding arrestees, or moving towards a universal database. The theoretical size of a DNA database can also be increased scientifically by using the inherent nature of DNA sharing by biologically related individuals by using an indirect matching strategy including Partial Matching, Familial Searching, and Investigative Genetic Genealogy (IGG). A new strategy is introduced using areas of shared DNA as a search key to locate potential relatives for further kinship evaluation. New search key strategies include Y-STR, mtDNA, and X Chromosome searching to locate potential relatives, coupled with kinship and genetic genealogical research, as well as expanded use of unidentified human remains (UHRs). Elsevier 2022-04-05 /pmc/articles/PMC8991311/ /pubmed/35402888 http://dx.doi.org/10.1016/j.fsisyn.2022.100226 Text en © 2022 The Author https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Policy and Management (in memory of Jay Siegel)
Wickenheiser, Ray A.
Expanding DNA database effectiveness
title Expanding DNA database effectiveness
title_full Expanding DNA database effectiveness
title_fullStr Expanding DNA database effectiveness
title_full_unstemmed Expanding DNA database effectiveness
title_short Expanding DNA database effectiveness
title_sort expanding dna database effectiveness
topic Policy and Management (in memory of Jay Siegel)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8991311/
https://www.ncbi.nlm.nih.gov/pubmed/35402888
http://dx.doi.org/10.1016/j.fsisyn.2022.100226
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