Cargando…

Is diabetic striatopathy the culprit of seizures in a patient with ketotic hyperglycemia-induced hemichorea–hemiballismus?

BACKGROUND: Diabetic striatopathy is a rare neurological manifestation of nonketotic hyperglycemia that presents with contralateral hemichorea-hemiballismus. Presentation with concurrent seizures is rarely reported. CLINICAL PRESENTATION: We report a case of diabetic striatopathy presenting with foc...

Descripción completa

Detalles Bibliográficos
Autores principales: Safan, Abeer Sabry, Sharma, Omna, Almasri, Muna, D’Souza, Ashton Ian, Suliman, Omer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8991619/
https://www.ncbi.nlm.nih.gov/pubmed/35395738
http://dx.doi.org/10.1186/s12883-022-02659-5
_version_ 1784683607015555072
author Safan, Abeer Sabry
Sharma, Omna
Almasri, Muna
D’Souza, Ashton Ian
Suliman, Omer
author_facet Safan, Abeer Sabry
Sharma, Omna
Almasri, Muna
D’Souza, Ashton Ian
Suliman, Omer
author_sort Safan, Abeer Sabry
collection PubMed
description BACKGROUND: Diabetic striatopathy is a rare neurological manifestation of nonketotic hyperglycemia that presents with contralateral hemichorea-hemiballismus. Presentation with concurrent seizures is rarely reported. CLINICAL PRESENTATION: We report a case of diabetic striatopathy presenting with focal and generalized tonic-clonic seizures (GTCS) with right hemichorea-hemiballismus induced by a ketotic hyperglycemic state. Head MRI showed high T1-weighted signal intensity in the left lentiform nucleus with no significant diffusion restriction or postcontrast enhancement. The patient’s condition gradually improved, with seizure control on AEDs. Hemichorea-hemiballismus significantly improved with adequate blood sugar control and resolved with low-dose haloperidol. CONCLUSIONS: Diabetic striatopathy presenting with hemichorea-hemiballismus and concurrent GTCS has been reported previously in two cases; however, it has never been reported in ketotic hyperglycemia. To the best of our knowledge, we herein report the first case report of focal and generalized seizures in a ketotic hyperglycemic state and mesial temporal sclerosis.
format Online
Article
Text
id pubmed-8991619
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-89916192022-04-09 Is diabetic striatopathy the culprit of seizures in a patient with ketotic hyperglycemia-induced hemichorea–hemiballismus? Safan, Abeer Sabry Sharma, Omna Almasri, Muna D’Souza, Ashton Ian Suliman, Omer BMC Neurol Case Report BACKGROUND: Diabetic striatopathy is a rare neurological manifestation of nonketotic hyperglycemia that presents with contralateral hemichorea-hemiballismus. Presentation with concurrent seizures is rarely reported. CLINICAL PRESENTATION: We report a case of diabetic striatopathy presenting with focal and generalized tonic-clonic seizures (GTCS) with right hemichorea-hemiballismus induced by a ketotic hyperglycemic state. Head MRI showed high T1-weighted signal intensity in the left lentiform nucleus with no significant diffusion restriction or postcontrast enhancement. The patient’s condition gradually improved, with seizure control on AEDs. Hemichorea-hemiballismus significantly improved with adequate blood sugar control and resolved with low-dose haloperidol. CONCLUSIONS: Diabetic striatopathy presenting with hemichorea-hemiballismus and concurrent GTCS has been reported previously in two cases; however, it has never been reported in ketotic hyperglycemia. To the best of our knowledge, we herein report the first case report of focal and generalized seizures in a ketotic hyperglycemic state and mesial temporal sclerosis. BioMed Central 2022-04-08 /pmc/articles/PMC8991619/ /pubmed/35395738 http://dx.doi.org/10.1186/s12883-022-02659-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Safan, Abeer Sabry
Sharma, Omna
Almasri, Muna
D’Souza, Ashton Ian
Suliman, Omer
Is diabetic striatopathy the culprit of seizures in a patient with ketotic hyperglycemia-induced hemichorea–hemiballismus?
title Is diabetic striatopathy the culprit of seizures in a patient with ketotic hyperglycemia-induced hemichorea–hemiballismus?
title_full Is diabetic striatopathy the culprit of seizures in a patient with ketotic hyperglycemia-induced hemichorea–hemiballismus?
title_fullStr Is diabetic striatopathy the culprit of seizures in a patient with ketotic hyperglycemia-induced hemichorea–hemiballismus?
title_full_unstemmed Is diabetic striatopathy the culprit of seizures in a patient with ketotic hyperglycemia-induced hemichorea–hemiballismus?
title_short Is diabetic striatopathy the culprit of seizures in a patient with ketotic hyperglycemia-induced hemichorea–hemiballismus?
title_sort is diabetic striatopathy the culprit of seizures in a patient with ketotic hyperglycemia-induced hemichorea–hemiballismus?
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8991619/
https://www.ncbi.nlm.nih.gov/pubmed/35395738
http://dx.doi.org/10.1186/s12883-022-02659-5
work_keys_str_mv AT safanabeersabry isdiabeticstriatopathytheculpritofseizuresinapatientwithketotichyperglycemiainducedhemichoreahemiballismus
AT sharmaomna isdiabeticstriatopathytheculpritofseizuresinapatientwithketotichyperglycemiainducedhemichoreahemiballismus
AT almasrimuna isdiabeticstriatopathytheculpritofseizuresinapatientwithketotichyperglycemiainducedhemichoreahemiballismus
AT dsouzaashtonian isdiabeticstriatopathytheculpritofseizuresinapatientwithketotichyperglycemiainducedhemichoreahemiballismus
AT sulimanomer isdiabeticstriatopathytheculpritofseizuresinapatientwithketotichyperglycemiainducedhemichoreahemiballismus