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Genetic heterogeneity on sleep disorders in Parkinson’s disease: a systematic review and meta-analysis

A growing amount of evidence has indicated contributions of variants in causative genes of Parkinson’s disease (PD) to the development of sleep disturbance in PD and prodromal PD stages. In this article, we aimed to investigate the role of genetics in sleep disorders in PD patients and asymptomatic...

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Autores principales: Huang, Jingxuan, Cheng, Yangfan, Li, Chunyu, Shang, Huifang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8991652/
https://www.ncbi.nlm.nih.gov/pubmed/35395825
http://dx.doi.org/10.1186/s40035-022-00294-1
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author Huang, Jingxuan
Cheng, Yangfan
Li, Chunyu
Shang, Huifang
author_facet Huang, Jingxuan
Cheng, Yangfan
Li, Chunyu
Shang, Huifang
author_sort Huang, Jingxuan
collection PubMed
description A growing amount of evidence has indicated contributions of variants in causative genes of Parkinson’s disease (PD) to the development of sleep disturbance in PD and prodromal PD stages. In this article, we aimed to investigate the role of genetics in sleep disorders in PD patients and asymptomatic carriers at prodromal stage of PD. A systematic review and meta-analysis of observational studies was conducted based on the MEDLINE, EMBASE and PsychINFO databases. A pooled effect size was calculated by odds ratio (OR) and standard mean difference (SMD). Forty studies were selected for quantitative analysis, including 17 studies on glucocerebrosidase (GBA), 25 studies on Leucine-rich repeat kinase 2 (LRRK2) and 7 on parkin (PRKN) genes, and 3 studies on alpha-synuclein gene (SNCA) were used for qualitative analysis. Patients with PD carrying GBA variants had a significantly higher risk for rapid-eye-movement behavior disorders (RBD) (OR, 1.82) and higher RBD Screening Questionnaire scores (SMD, 0.33). Asymptomatic carriers of GBA variants had higher severity of RBD during follow-up. Patients with PD carrying the LRRK2 G2019S variant had lower risk and severity of RBD compared with those without LRRK2 G2019S. Variants of GBA, LRRK2 and PRKN did not increase or decrease the risk and severity of excessive daytime sleepiness and restless legs syndrome in PD. Our findings suggest that the genetic heterogeneity plays a role in the development of sleep disorders, mainly RBD, in PD and the prodromal stage of PD. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40035-022-00294-1.
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spelling pubmed-89916522022-04-09 Genetic heterogeneity on sleep disorders in Parkinson’s disease: a systematic review and meta-analysis Huang, Jingxuan Cheng, Yangfan Li, Chunyu Shang, Huifang Transl Neurodegener Review A growing amount of evidence has indicated contributions of variants in causative genes of Parkinson’s disease (PD) to the development of sleep disturbance in PD and prodromal PD stages. In this article, we aimed to investigate the role of genetics in sleep disorders in PD patients and asymptomatic carriers at prodromal stage of PD. A systematic review and meta-analysis of observational studies was conducted based on the MEDLINE, EMBASE and PsychINFO databases. A pooled effect size was calculated by odds ratio (OR) and standard mean difference (SMD). Forty studies were selected for quantitative analysis, including 17 studies on glucocerebrosidase (GBA), 25 studies on Leucine-rich repeat kinase 2 (LRRK2) and 7 on parkin (PRKN) genes, and 3 studies on alpha-synuclein gene (SNCA) were used for qualitative analysis. Patients with PD carrying GBA variants had a significantly higher risk for rapid-eye-movement behavior disorders (RBD) (OR, 1.82) and higher RBD Screening Questionnaire scores (SMD, 0.33). Asymptomatic carriers of GBA variants had higher severity of RBD during follow-up. Patients with PD carrying the LRRK2 G2019S variant had lower risk and severity of RBD compared with those without LRRK2 G2019S. Variants of GBA, LRRK2 and PRKN did not increase or decrease the risk and severity of excessive daytime sleepiness and restless legs syndrome in PD. Our findings suggest that the genetic heterogeneity plays a role in the development of sleep disorders, mainly RBD, in PD and the prodromal stage of PD. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40035-022-00294-1. BioMed Central 2022-04-08 /pmc/articles/PMC8991652/ /pubmed/35395825 http://dx.doi.org/10.1186/s40035-022-00294-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Huang, Jingxuan
Cheng, Yangfan
Li, Chunyu
Shang, Huifang
Genetic heterogeneity on sleep disorders in Parkinson’s disease: a systematic review and meta-analysis
title Genetic heterogeneity on sleep disorders in Parkinson’s disease: a systematic review and meta-analysis
title_full Genetic heterogeneity on sleep disorders in Parkinson’s disease: a systematic review and meta-analysis
title_fullStr Genetic heterogeneity on sleep disorders in Parkinson’s disease: a systematic review and meta-analysis
title_full_unstemmed Genetic heterogeneity on sleep disorders in Parkinson’s disease: a systematic review and meta-analysis
title_short Genetic heterogeneity on sleep disorders in Parkinson’s disease: a systematic review and meta-analysis
title_sort genetic heterogeneity on sleep disorders in parkinson’s disease: a systematic review and meta-analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8991652/
https://www.ncbi.nlm.nih.gov/pubmed/35395825
http://dx.doi.org/10.1186/s40035-022-00294-1
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