Cargando…

Altered Signaling Pathways Revealed by Comprehensive Genomic Profiling in Patients With Unknown Primary Tumors

PURPOSE: Carcinoma of unknown primary (CUP) is a clinically aggressive disorder with early tumor dissemination. Identifying molecular traits of CUP can be not only beneficial for a better therapeutic approach but also potentially valuable for patients with general metastatic dissemination. PATIENTS...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Zhen, Cui, Wei, Yu, Ruoying, Dong, Xinhua, Zhao, Jian, Dai, Lu, Ou, Qiuxiang, Bao, Hua, Wu, Xue, Wu, Chuanxin, Lai, Jinhuo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8991684/ https://www.ncbi.nlm.nih.gov/pubmed/35402276 http://dx.doi.org/10.3389/fonc.2022.753311

Ejemplares similares

Comprehensive genomic profiling of colorectal cancer patients reveals differences in mutational landscapes among clinical and pathological subgroups
por: Li, Peng, et al.
Publicado: (2022)

Clinical and molecular characteristics of kinase domain duplications across diverse cancer types in the Chinese population
por: Lai, Xiaojing, et al.
Publicado: (2022)

Pan‐cancer molecular analysis of EGFR large fragment deletion in the Asian population
por: Pu, Jun, et al.
Publicado: (2023)

LAPS score for individualized treatment of advanced EGFR-mutated non-small cell lung cancer receiving EGFR-TKIs with or without bevacizumab
por: Wu, Yahua, et al.
Publicado: (2023)

Comprehensive characterization of FBXW7 mutational and clinicopathological profiles in human colorectal cancers
por: Liu, Yiping, et al.
Publicado: (2023)

90-Gene Expression Profiling for Tissue Origin Diagnosis of Cancer of Unknown Primary
por: Zhang, Yi, et al.
Publicado: (2021)

The enrichment of Fanconi anemia/homologous recombination pathway aberrations in ATM/ATR-mutated NSCLC was accompanied by unique molecular features and poor prognosis
por: Wei, Wei, et al.
Publicado: (2023)

Comprehensive genomic profiling reveals prognostic signatures and insights into the molecular landscape of colorectal cancer
por: Yang, Jinwei, et al.
Publicado: (2023)

Comprehensive Analysis of the Oncogenic, Genomic Alteration, and Immunological Landscape of Cation-Chloride Cotransporters in Pan-Cancer
por: Wang, Jie, et al.
Publicado: (2022)

Case Report: Tissue Origin Identification for Cancer of Unknown Primary: Gene Expression Profiling Approach
por: Pu, Xingxiang, et al.
Publicado: (2021)

Comprehensive Profiling of Gene Copy Number Alterations Predicts Patient Prognosis in Resected Stages I–III Lung Adenocarcinoma
por: Han, Xiaohong, et al.
Publicado: (2019)

First-generation EGFR-TKI plus bevacizumab and chemotherapy for advanced EGFR-mutated non-squamous non-small-cell lung cancer: a retrospective study
por: Wu, Yahua, et al.
Publicado: (2023)

Genomic Profiling of Chinese Cervical Cancer Patients Reveals Prevalence of DNA Damage Repair Gene Alterations and Related Hypoxia Feature
por: Wen, Hao, et al.
Publicado: (2022)

Clinical utility of cerebrospinal fluid-derived circular RNAs in lung adenocarcinoma patients with brain metastases
por: Wang, Zhen, et al.
Publicado: (2022)

Comprehensive genomic profiling aids in understanding the lesion origins of a patient with six synchronous invasive lung adenocarcinomas: a case study
por: Song, Yang, et al.
Publicado: (2020)

Durable Complete Response to Alectinib in a Lung Adenocarcinoma Patient With Brain Metastases and Low-Abundance EML4-ALK Variant in Liquid Biopsy: A Case Report
por: Zhu, Yingying, et al.
Publicado: (2020)

Case Report: Molecular Profiling Assists in the Diagnosis and Treatment of Cancer of Unknown Primary
por: Yu, Bo, et al.
Publicado: (2022)

Diagnosis and Treatment of Male Accessory Breast Cancer: A Comprehensive Systematic Review
por: Pang, Liwei, et al.
Publicado: (2021)

Genomic Profiling Reveals Synchronous Bilateral Lung Adenocarcinomas With Distinct Driver Alterations of EML4-ALK or TPM3-ROS1 Fusion: A Case Report
por: Tan, Benxu, et al.
Publicado: (2019)

Uterine perivascular epithelioid tumors (PEComas) with lung metastasis showed good responses to mTOR and VEGFR inhibitors: A case report
por: Sui, Chengxu, et al.
Publicado: (2022)

Comprehensive Characterization of Immunological Profiles and Clinical Significance in Hepatocellular Carcinoma
por: Tao, Ping, et al.
Publicado: (2021)

RNA-Seq Profiling of Serum Exosomal Circular RNAs Reveals Circ-PNN as a Potential Biomarker for Human Colorectal Cancer
por: Xie, Yan, et al.
Publicado: (2020)

Comprehensive Genomic Profiling of Rare Tumors: Routes to Targeted Therapies
por: Wang, Shuhang, et al.
Publicado: (2020)

Comprehensive Analysis of Prognostic Alternative Splicing Signature Reveals Recurrence Predictor for Papillary Thyroid Cancer
por: Liu, Mian, et al.
Publicado: (2021)

Genomic Profiling Reveals the Molecular Landscape of Gastrointestinal Tract Cancers in Chinese Patients
por: Zhu, Chunrong, et al.
Publicado: (2021)

Comprehensive genomic profiling: Does timing matter?
por: Thapa, Bicky, et al.
Publicado: (2023)

Updates in the management of unknown primary of the head and neck
por: Kalavacherla, Sandhya, et al.
Publicado: (2022)

Genomic Profiling Reveals Novel Predictive Biomarkers for Chemo-Radiotherapy Efficacy and Thoracic Toxicity in Non-Small-Cell Lung Cancer
por: He, Kewen, et al.
Publicado: (2022)

Immune microenvironment analysis and novel biomarkers of early-stage lung adenocarcinoma evolution
por: Liu, Jun, et al.
Publicado: (2023)

Long-Term Clinical Benefit in EGFR-Mutant Lung Adenocarcinoma With Local Squamous Cell Carcinoma Transformation After EGFR TKI Resistance: A Case Report
por: Ye, Junru, et al.
Publicado: (2022)

Comprehensive Analysis of the Function, Immune Profiles, and Clinical Implication of m1A Regulators in Lung Adenocarcinoma
por: Bao, Guangyao, et al.
Publicado: (2022)

Comprehensive Analysis of Regulatory Networks of m6A Regulators and Reveals Prognosis Biomarkers in Sarcoma
por: Pang, Boran, et al.
Publicado: (2022)

Metastatic urothelial carcinoma to the liver with unknown primary tumor
por: Cheung, Carling, et al.
Publicado: (2019)

“Metastatic Cancer of Unknown Primary” or “Primary Metastatic Cancer”?
por: Kolling, Stefan, et al.
Publicado: (2020)

A Comprehensive Analysis of Alterations in DNA Damage Repair Pathways Reveals a Potential Way to Enhance the Radio-Sensitivity of Esophageal Squamous Cell Cancer
por: Wang, Guangchao, et al.
Publicado: (2020)

Transcriptomic Profiling Revealed Plexin A2 Downregulation With Migration and Invasion Alteration in Dacarbazine-Treated Primary Melanoma Cells
por: Tyumentseva, Anna, et al.
Publicado: (2021)

Molecular genetic characterization reveals linear tumor evolution in a pulmonary sarcomatoid carcinomas patient with a novel PHF20-NTRK1 fusion: a case report
por: Ge, Jianjun, et al.
Publicado: (2019)

Significance of the Neutrophil-to-Lymphocyte Ratio in p16-Negative Squamous Cell Carcinoma of Unknown Primary in Head and Neck
por: Xu, Chunmiao, et al.
Publicado: (2020)

Expression of Glycolysis-Related Proteins in Cancer of Unknown Primary Origin
por: Bonatelli, Murilo, et al.
Publicado: (2021)

Targeted therapy in NPM1-mutated AML: Knowns and unknowns
por: Wang, Rong, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_qhj9gauqrs4m03c3pdh36lhigf