HIV-1-infection in a man who has sex with men despite self-reported excellent adherence to pre-exposure prophylaxis, the Netherlands, August 2021: be alert to emtricitabine/tenofovir-resistant strain transmission

In August 2021, a man who has sex with men was diagnosed with HIV-1 infection despite using event-driven pre-exposure prophylaxis for over 2 years with self-reported excellent adherence. Sequencing identified resistance-associated mutations (RAM) M184V and K65R, conferring resistance to emtricitabin...

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Autores principales: Koole, Jeffrey CD, de la Court, Feline, Welkers, Matthijs RA, Yap, Kenneth, Stalenhoef, Janneke E, Jurriaans, Suzanne, de Vries, Henry JC, Op de Coul, Eline LM, Prins, Maria, Hoornenborg, Elske
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2022
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8991733/
https://www.ncbi.nlm.nih.gov/pubmed/35393931
http://dx.doi.org/10.2807/1560-7917.ES.2022.27.14.2200275
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author Koole, Jeffrey CD
de la Court, Feline
Welkers, Matthijs RA
Yap, Kenneth
Stalenhoef, Janneke E
Jurriaans, Suzanne
de Vries, Henry JC
Op de Coul, Eline LM
Prins, Maria
Hoornenborg, Elske
author_facet Koole, Jeffrey CD
de la Court, Feline
Welkers, Matthijs RA
Yap, Kenneth
Stalenhoef, Janneke E
Jurriaans, Suzanne
de Vries, Henry JC
Op de Coul, Eline LM
Prins, Maria
Hoornenborg, Elske
author_sort Koole, Jeffrey CD
collection PubMed
description In August 2021, a man who has sex with men was diagnosed with HIV-1 infection despite using event-driven pre-exposure prophylaxis for over 2 years with self-reported excellent adherence. Sequencing identified resistance-associated mutations (RAM) M184V and K65R, conferring resistance to emtricitabine and tenofovir, and RAM V108I and E138A. Background RAM prevalence was two of 164 (1.2%) new HIV diagnoses in Amsterdam (2017–19). We reiterate the need for frequent HIV testing among PrEP users and additional testing in case of symptoms.
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spelling pubmed-89917332022-04-18 HIV-1-infection in a man who has sex with men despite self-reported excellent adherence to pre-exposure prophylaxis, the Netherlands, August 2021: be alert to emtricitabine/tenofovir-resistant strain transmission Koole, Jeffrey CD de la Court, Feline Welkers, Matthijs RA Yap, Kenneth Stalenhoef, Janneke E Jurriaans, Suzanne de Vries, Henry JC Op de Coul, Eline LM Prins, Maria Hoornenborg, Elske Euro Surveill Rapid Communication In August 2021, a man who has sex with men was diagnosed with HIV-1 infection despite using event-driven pre-exposure prophylaxis for over 2 years with self-reported excellent adherence. Sequencing identified resistance-associated mutations (RAM) M184V and K65R, conferring resistance to emtricitabine and tenofovir, and RAM V108I and E138A. Background RAM prevalence was two of 164 (1.2%) new HIV diagnoses in Amsterdam (2017–19). We reiterate the need for frequent HIV testing among PrEP users and additional testing in case of symptoms. European Centre for Disease Prevention and Control (ECDC) 2022-04-07 /pmc/articles/PMC8991733/ /pubmed/35393931 http://dx.doi.org/10.2807/1560-7917.ES.2022.27.14.2200275 Text en This article is copyright of the authors or their affiliated institutions, 2022. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Rapid Communication
Koole, Jeffrey CD
de la Court, Feline
Welkers, Matthijs RA
Yap, Kenneth
Stalenhoef, Janneke E
Jurriaans, Suzanne
de Vries, Henry JC
Op de Coul, Eline LM
Prins, Maria
Hoornenborg, Elske
HIV-1-infection in a man who has sex with men despite self-reported excellent adherence to pre-exposure prophylaxis, the Netherlands, August 2021: be alert to emtricitabine/tenofovir-resistant strain transmission
title HIV-1-infection in a man who has sex with men despite self-reported excellent adherence to pre-exposure prophylaxis, the Netherlands, August 2021: be alert to emtricitabine/tenofovir-resistant strain transmission
title_full HIV-1-infection in a man who has sex with men despite self-reported excellent adherence to pre-exposure prophylaxis, the Netherlands, August 2021: be alert to emtricitabine/tenofovir-resistant strain transmission
title_fullStr HIV-1-infection in a man who has sex with men despite self-reported excellent adherence to pre-exposure prophylaxis, the Netherlands, August 2021: be alert to emtricitabine/tenofovir-resistant strain transmission
title_full_unstemmed HIV-1-infection in a man who has sex with men despite self-reported excellent adherence to pre-exposure prophylaxis, the Netherlands, August 2021: be alert to emtricitabine/tenofovir-resistant strain transmission
title_short HIV-1-infection in a man who has sex with men despite self-reported excellent adherence to pre-exposure prophylaxis, the Netherlands, August 2021: be alert to emtricitabine/tenofovir-resistant strain transmission
title_sort hiv-1-infection in a man who has sex with men despite self-reported excellent adherence to pre-exposure prophylaxis, the netherlands, august 2021: be alert to emtricitabine/tenofovir-resistant strain transmission
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8991733/
https://www.ncbi.nlm.nih.gov/pubmed/35393931
http://dx.doi.org/10.2807/1560-7917.ES.2022.27.14.2200275
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