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Adolescence exposure to China’s great famine period and the association of metabolic syndrome in adulthood: a retrospective study

BACKGROUND: Exposure to famine during early life is related to several adverse health outcomes in adulthood, but the effect of famine exposure during adolescence is unclear. This study aims to examine whether exposure to famine in adolescence is associated with metabolic syndrome (MetS) in adulthood...

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Autores principales: Sun, Ning, Li, Wei, Osibogun, Olatokunbo, Kalan, Mohammad Ebrahimi, Jebai, Rime, Gautam, Prem, Taskin, Tanjila, Yin, Wupeng, Jones, Jeffery A., Gamber, Michelle, Sun, Wenjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8991788/
https://www.ncbi.nlm.nih.gov/pubmed/35395755
http://dx.doi.org/10.1186/s12889-022-13047-6
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author Sun, Ning
Li, Wei
Osibogun, Olatokunbo
Kalan, Mohammad Ebrahimi
Jebai, Rime
Gautam, Prem
Taskin, Tanjila
Yin, Wupeng
Jones, Jeffery A.
Gamber, Michelle
Sun, Wenjie
author_facet Sun, Ning
Li, Wei
Osibogun, Olatokunbo
Kalan, Mohammad Ebrahimi
Jebai, Rime
Gautam, Prem
Taskin, Tanjila
Yin, Wupeng
Jones, Jeffery A.
Gamber, Michelle
Sun, Wenjie
author_sort Sun, Ning
collection PubMed
description BACKGROUND: Exposure to famine during early life is related to several adverse health outcomes in adulthood, but the effect of famine exposure during adolescence is unclear. This study aims to examine whether exposure to famine in adolescence is associated with metabolic syndrome (MetS) in adulthood. METHODS: This study included 4130 Chinese adults (2059 males and 2071 females) aged 59–71 from the 2011 China Health and Retirement Longitudinal Study (CHARLS). All the selected participants were exposed to the three-year time period (1959–1961) of China’s Great Famine. Participants were categorized into an adolescent-exposed group (born 01/01/1944–12/31/1948) and a non-adolescent-exposed group (born 01/01/1940–12/31/1941 and 01/01/1951–12/31/1952). Sex-stratified multiple logistic regression models were used to estimate the association between exposure to famine in adolescence and MetS. RESULTS: Participants exposed to famine during adolescence were more likely to report MetS (aOR = 1.35; 95%CI 1.01–1.78) compared to the non-adolescent-exposed group. Further, males were 45% less likely to report MetS than females (aOR = 0.55; 95%CI 0.36–0.83). After stratification by sex, the effects of famine exposure during adolescence on MetS were detected among males only (aOR = 1.97; 95%CI 1.20–3.24). Additionally, males with a history of drinking were more likely to report MetS compared to those with no history of drinking (aOR = 2.63; 95%CI 1.41–4.90). CONCLUSIONS: Our findings reveal that exposure to famine during adolescence is associated with higher odds of MetS in adulthood overall, and this association is only pronounced among males. This study emphasizes that undernutrition in early life, including adolescence, may have a long-term effect and be associated with adverse health events in middle-to-late life. Targeting those elderly people who suffered famine during adolescence may help prevent the development of MetS in later life.
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spelling pubmed-89917882022-04-09 Adolescence exposure to China’s great famine period and the association of metabolic syndrome in adulthood: a retrospective study Sun, Ning Li, Wei Osibogun, Olatokunbo Kalan, Mohammad Ebrahimi Jebai, Rime Gautam, Prem Taskin, Tanjila Yin, Wupeng Jones, Jeffery A. Gamber, Michelle Sun, Wenjie BMC Public Health Research BACKGROUND: Exposure to famine during early life is related to several adverse health outcomes in adulthood, but the effect of famine exposure during adolescence is unclear. This study aims to examine whether exposure to famine in adolescence is associated with metabolic syndrome (MetS) in adulthood. METHODS: This study included 4130 Chinese adults (2059 males and 2071 females) aged 59–71 from the 2011 China Health and Retirement Longitudinal Study (CHARLS). All the selected participants were exposed to the three-year time period (1959–1961) of China’s Great Famine. Participants were categorized into an adolescent-exposed group (born 01/01/1944–12/31/1948) and a non-adolescent-exposed group (born 01/01/1940–12/31/1941 and 01/01/1951–12/31/1952). Sex-stratified multiple logistic regression models were used to estimate the association between exposure to famine in adolescence and MetS. RESULTS: Participants exposed to famine during adolescence were more likely to report MetS (aOR = 1.35; 95%CI 1.01–1.78) compared to the non-adolescent-exposed group. Further, males were 45% less likely to report MetS than females (aOR = 0.55; 95%CI 0.36–0.83). After stratification by sex, the effects of famine exposure during adolescence on MetS were detected among males only (aOR = 1.97; 95%CI 1.20–3.24). Additionally, males with a history of drinking were more likely to report MetS compared to those with no history of drinking (aOR = 2.63; 95%CI 1.41–4.90). CONCLUSIONS: Our findings reveal that exposure to famine during adolescence is associated with higher odds of MetS in adulthood overall, and this association is only pronounced among males. This study emphasizes that undernutrition in early life, including adolescence, may have a long-term effect and be associated with adverse health events in middle-to-late life. Targeting those elderly people who suffered famine during adolescence may help prevent the development of MetS in later life. BioMed Central 2022-04-08 /pmc/articles/PMC8991788/ /pubmed/35395755 http://dx.doi.org/10.1186/s12889-022-13047-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Sun, Ning
Li, Wei
Osibogun, Olatokunbo
Kalan, Mohammad Ebrahimi
Jebai, Rime
Gautam, Prem
Taskin, Tanjila
Yin, Wupeng
Jones, Jeffery A.
Gamber, Michelle
Sun, Wenjie
Adolescence exposure to China’s great famine period and the association of metabolic syndrome in adulthood: a retrospective study
title Adolescence exposure to China’s great famine period and the association of metabolic syndrome in adulthood: a retrospective study
title_full Adolescence exposure to China’s great famine period and the association of metabolic syndrome in adulthood: a retrospective study
title_fullStr Adolescence exposure to China’s great famine period and the association of metabolic syndrome in adulthood: a retrospective study
title_full_unstemmed Adolescence exposure to China’s great famine period and the association of metabolic syndrome in adulthood: a retrospective study
title_short Adolescence exposure to China’s great famine period and the association of metabolic syndrome in adulthood: a retrospective study
title_sort adolescence exposure to china’s great famine period and the association of metabolic syndrome in adulthood: a retrospective study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8991788/
https://www.ncbi.nlm.nih.gov/pubmed/35395755
http://dx.doi.org/10.1186/s12889-022-13047-6
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