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Ti(3)C(2) nanosheets with broad-spectrum antioxidant activity for cytoprotection against oxidative stress
Redox regulation in biological systems represents a fascinating method for treatment and prevention of oxidative stress induced diseases. The key and difficult point is to find ideal materials with excellent antioxidant capability and good biocompatibility. To this end, ultra-thin two-dimensional MX...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8991840/ https://www.ncbi.nlm.nih.gov/pubmed/35425035 http://dx.doi.org/10.1039/d2ra01225a |
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author | Geng, Hongqi Ren, Yaping Qin, Gang Wen, Tao Liu, Quan Xu, Haiyan He, Weiwei |
author_facet | Geng, Hongqi Ren, Yaping Qin, Gang Wen, Tao Liu, Quan Xu, Haiyan He, Weiwei |
author_sort | Geng, Hongqi |
collection | PubMed |
description | Redox regulation in biological systems represents a fascinating method for treatment and prevention of oxidative stress induced diseases. The key and difficult point is to find ideal materials with excellent antioxidant capability and good biocompatibility. To this end, ultra-thin two-dimensional MXene (Ti(3)C(2)) nanosheets (NSs) were investigated for their antioxidant capability. It is found that Ti(3)C(2) NSs can scavenge efficiently reactive oxygen and nitrogen species (˙OH, H(2)O(2), [Image: see text] and ˙NO), ABTS(+)˙ and DPPH˙ free radicals in a concentration dependent manner, showing broad-spectrum antioxidant activities. Ti(3)C(2) NSs exhibit higher antioxidant activity and broader antioxidant capability than natural antioxidant molecules. The significant role of PEG modified Ti(3)C(2) with good stability in preventing cell damage against oxidative stress was demonstrated. Upon treatment of H(2)O(2) induced oxidative stress with Ti(3)C(2), the intracellular ROS level decreases and the cell survival rate increases significantly. An antioxidant mechanism based on gradient oxidation was proposed to account for the superior antioxidant activity of Ti(3)C(2). Our result proves that ultra-thin MXenes as antioxidants have great potential in preventing oxidative stress caused biological damage. |
format | Online Article Text |
id | pubmed-8991840 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-89918402022-04-13 Ti(3)C(2) nanosheets with broad-spectrum antioxidant activity for cytoprotection against oxidative stress Geng, Hongqi Ren, Yaping Qin, Gang Wen, Tao Liu, Quan Xu, Haiyan He, Weiwei RSC Adv Chemistry Redox regulation in biological systems represents a fascinating method for treatment and prevention of oxidative stress induced diseases. The key and difficult point is to find ideal materials with excellent antioxidant capability and good biocompatibility. To this end, ultra-thin two-dimensional MXene (Ti(3)C(2)) nanosheets (NSs) were investigated for their antioxidant capability. It is found that Ti(3)C(2) NSs can scavenge efficiently reactive oxygen and nitrogen species (˙OH, H(2)O(2), [Image: see text] and ˙NO), ABTS(+)˙ and DPPH˙ free radicals in a concentration dependent manner, showing broad-spectrum antioxidant activities. Ti(3)C(2) NSs exhibit higher antioxidant activity and broader antioxidant capability than natural antioxidant molecules. The significant role of PEG modified Ti(3)C(2) with good stability in preventing cell damage against oxidative stress was demonstrated. Upon treatment of H(2)O(2) induced oxidative stress with Ti(3)C(2), the intracellular ROS level decreases and the cell survival rate increases significantly. An antioxidant mechanism based on gradient oxidation was proposed to account for the superior antioxidant activity of Ti(3)C(2). Our result proves that ultra-thin MXenes as antioxidants have great potential in preventing oxidative stress caused biological damage. The Royal Society of Chemistry 2022-04-08 /pmc/articles/PMC8991840/ /pubmed/35425035 http://dx.doi.org/10.1039/d2ra01225a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/ |
spellingShingle | Chemistry Geng, Hongqi Ren, Yaping Qin, Gang Wen, Tao Liu, Quan Xu, Haiyan He, Weiwei Ti(3)C(2) nanosheets with broad-spectrum antioxidant activity for cytoprotection against oxidative stress |
title | Ti(3)C(2) nanosheets with broad-spectrum antioxidant activity for cytoprotection against oxidative stress |
title_full | Ti(3)C(2) nanosheets with broad-spectrum antioxidant activity for cytoprotection against oxidative stress |
title_fullStr | Ti(3)C(2) nanosheets with broad-spectrum antioxidant activity for cytoprotection against oxidative stress |
title_full_unstemmed | Ti(3)C(2) nanosheets with broad-spectrum antioxidant activity for cytoprotection against oxidative stress |
title_short | Ti(3)C(2) nanosheets with broad-spectrum antioxidant activity for cytoprotection against oxidative stress |
title_sort | ti(3)c(2) nanosheets with broad-spectrum antioxidant activity for cytoprotection against oxidative stress |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8991840/ https://www.ncbi.nlm.nih.gov/pubmed/35425035 http://dx.doi.org/10.1039/d2ra01225a |
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