Potential application of hydrogel to the diagnosis and treatment of multiple sclerosis

ABSTRACT: Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system. This disorder may cause progressive and permanent impairment, placing significant physical and psychological strain on sufferers. Each progress in MS therapy marks a significant advancement in neurolo...

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Autores principales: Liu, Haochuan, Chen, Bing, Zhu, Qingsan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8991948/
https://www.ncbi.nlm.nih.gov/pubmed/35395765
http://dx.doi.org/10.1186/s13036-022-00288-7
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author Liu, Haochuan
Chen, Bing
Zhu, Qingsan
author_facet Liu, Haochuan
Chen, Bing
Zhu, Qingsan
author_sort Liu, Haochuan
collection PubMed
description ABSTRACT: Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system. This disorder may cause progressive and permanent impairment, placing significant physical and psychological strain on sufferers. Each progress in MS therapy marks a significant advancement in neurological research. Hydrogels can serve as a scaffold with high water content, high expansibility, and biocompatibility to improve MS cell proliferation in vitro and therapeutic drug delivery to cells in vivo. Hydrogels may also be utilized as biosensors to detect MS-related proteins. Recent research has employed hydrogels as an adjuvant imaging agent in immunohistochemistry assays. Following an overview of the development and use of hydrogels in MS diagnostic and therapy, this review discussed hydrogel’s advantages and future opportunities in the diagnosis and treatment of MS. GRAPHICAL ABSTRACT: [Image: see text]
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spelling pubmed-89919482022-04-09 Potential application of hydrogel to the diagnosis and treatment of multiple sclerosis Liu, Haochuan Chen, Bing Zhu, Qingsan J Biol Eng Review ABSTRACT: Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system. This disorder may cause progressive and permanent impairment, placing significant physical and psychological strain on sufferers. Each progress in MS therapy marks a significant advancement in neurological research. Hydrogels can serve as a scaffold with high water content, high expansibility, and biocompatibility to improve MS cell proliferation in vitro and therapeutic drug delivery to cells in vivo. Hydrogels may also be utilized as biosensors to detect MS-related proteins. Recent research has employed hydrogels as an adjuvant imaging agent in immunohistochemistry assays. Following an overview of the development and use of hydrogels in MS diagnostic and therapy, this review discussed hydrogel’s advantages and future opportunities in the diagnosis and treatment of MS. GRAPHICAL ABSTRACT: [Image: see text] BioMed Central 2022-04-08 /pmc/articles/PMC8991948/ /pubmed/35395765 http://dx.doi.org/10.1186/s13036-022-00288-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Liu, Haochuan
Chen, Bing
Zhu, Qingsan
Potential application of hydrogel to the diagnosis and treatment of multiple sclerosis
title Potential application of hydrogel to the diagnosis and treatment of multiple sclerosis
title_full Potential application of hydrogel to the diagnosis and treatment of multiple sclerosis
title_fullStr Potential application of hydrogel to the diagnosis and treatment of multiple sclerosis
title_full_unstemmed Potential application of hydrogel to the diagnosis and treatment of multiple sclerosis
title_short Potential application of hydrogel to the diagnosis and treatment of multiple sclerosis
title_sort potential application of hydrogel to the diagnosis and treatment of multiple sclerosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8991948/
https://www.ncbi.nlm.nih.gov/pubmed/35395765
http://dx.doi.org/10.1186/s13036-022-00288-7
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AT zhuqingsan potentialapplicationofhydrogeltothediagnosisandtreatmentofmultiplesclerosis

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