Multi-omics data integration analysis identifies the spliceosome as a key regulator of DNA double-strand break repair

DNA repair by homologous recombination (HR) is critical for the maintenance of genome stability. Germline and somatic mutations in HR genes have been associated with an increased risk of developing breast (BC) and ovarian cancers (OvC). However, the extent of factors and pathways that are functional...

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Detalles Bibliográficos
Autores principales: Sherill-Rofe, Dana, Raban, Oded, Findlay, Steven, Rahat, Dolev, Unterman, Irene, Samiei, Arash, Yasmeen, Amber, Kaiser, Zafir, Kuasne, Hellen, Park, Morag, Foulkes, William D, Bloch, Idit, Zick, Aviad, Gotlieb, Walter H, Tabach, Yuval, Orthwein, Alexandre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Cancer Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8991968/
https://www.ncbi.nlm.nih.gov/pubmed/35399185
http://dx.doi.org/10.1093/narcan/zcac013

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