Peptides GWN and GW protect kidney cells against Dasatinib induced mitochondrial injury in a SIRT1 dependent manner

Dasatinib, a small-molecule drug used as a treatment for chronic myeloid leukemia induces mitochondrial damage in embryonic kidney (293 T) cells (p < 0.05). This dasatinib induced mitochondrial injury in kidney cells was mitigated by H3K36me3 activating ovotransferrin-derived peptides GWN and GW....

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Detalles Bibliográficos
Autores principales: Bhullar, Khushwant S., Ashkar, Fatemeh, Wu, Jianping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article(s) from the Special Issue on Proteomic approaches in the identification of food proteins and peptides by Dr Toldrá and Dr. Mora
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8991994/
https://www.ncbi.nlm.nih.gov/pubmed/35415678
http://dx.doi.org/10.1016/j.fochms.2021.100069

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