A concise and efficient total synthetic route of active stilbene dimer (±)-ε-viniferin

A concise and efficient procedure for the total synthesis of natural stilbene dimer (±)-ε-viniferin was accomplished with high overall yield. Demethylation of the key intermediate methyl 3-arylbenzofuran-4-carboxylate was achieved successfully through bromination followed by BBr(3)-or BCl(3)/TBAI-me...

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Detalles Bibliográficos
Autores principales: Zhu, Qibin, Teng, Binhao, Chen, Ying, Su, Fubao, Li, Yanqiu, Yang, Qingyun, Yao, Chunsuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8992221/
https://www.ncbi.nlm.nih.gov/pubmed/35425053
http://dx.doi.org/10.1039/d2ra01385a
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author Zhu, Qibin
Teng, Binhao
Chen, Ying
Su, Fubao
Li, Yanqiu
Yang, Qingyun
Yao, Chunsuo
author_facet Zhu, Qibin
Teng, Binhao
Chen, Ying
Su, Fubao
Li, Yanqiu
Yang, Qingyun
Yao, Chunsuo
author_sort Zhu, Qibin
collection PubMed
description A concise and efficient procedure for the total synthesis of natural stilbene dimer (±)-ε-viniferin was accomplished with high overall yield. Demethylation of the key intermediate methyl 3-arylbenzofuran-4-carboxylate was achieved successfully through bromination followed by BBr(3)-or BCl(3)/TBAI-mediated ether cleavage reaction. Pd/C and bromobenzene-catalyzed MOM ether cleavage was successfully carried out to aquire (±)-ε-viniferin.
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spelling pubmed-89922212022-04-13 A concise and efficient total synthetic route of active stilbene dimer (±)-ε-viniferin Zhu, Qibin Teng, Binhao Chen, Ying Su, Fubao Li, Yanqiu Yang, Qingyun Yao, Chunsuo RSC Adv Chemistry A concise and efficient procedure for the total synthesis of natural stilbene dimer (±)-ε-viniferin was accomplished with high overall yield. Demethylation of the key intermediate methyl 3-arylbenzofuran-4-carboxylate was achieved successfully through bromination followed by BBr(3)-or BCl(3)/TBAI-mediated ether cleavage reaction. Pd/C and bromobenzene-catalyzed MOM ether cleavage was successfully carried out to aquire (±)-ε-viniferin. The Royal Society of Chemistry 2022-04-08 /pmc/articles/PMC8992221/ /pubmed/35425053 http://dx.doi.org/10.1039/d2ra01385a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Zhu, Qibin
Teng, Binhao
Chen, Ying
Su, Fubao
Li, Yanqiu
Yang, Qingyun
Yao, Chunsuo
A concise and efficient total synthetic route of active stilbene dimer (±)-ε-viniferin
title A concise and efficient total synthetic route of active stilbene dimer (±)-ε-viniferin
title_full A concise and efficient total synthetic route of active stilbene dimer (±)-ε-viniferin
title_fullStr A concise and efficient total synthetic route of active stilbene dimer (±)-ε-viniferin
title_full_unstemmed A concise and efficient total synthetic route of active stilbene dimer (±)-ε-viniferin
title_short A concise and efficient total synthetic route of active stilbene dimer (±)-ε-viniferin
title_sort concise and efficient total synthetic route of active stilbene dimer (±)-ε-viniferin
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8992221/
https://www.ncbi.nlm.nih.gov/pubmed/35425053
http://dx.doi.org/10.1039/d2ra01385a
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