Cargando…
Synthesis and Characterization of an Inclusion Complex of dl-Aminoglutethimide with β-Cyclodextrin and Its Innovative Application in a Biological System: Computational and Experimental Investigations
[Image: see text] Our present study intended to investigate the encapsulation of DL-AGT within the lipophilic cavity of a β-CD molecule. The consequential inclusion system was characterized by UV–visible spectroscopy and (1)H NMR, PXRD, SEM, and FT-IR studies. Molecular docking was performed for the...
| Autores principales: | , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2022
|
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8992260/ https://www.ncbi.nlm.nih.gov/pubmed/35415366 http://dx.doi.org/10.1021/acsomega.2c00011 |
| _version_ | 1784683699658293248 |
|---|---|
| author | Ray, Samapika Roy, Niloy Barman, Biraj Kumar Karmakar, Paramita Bomzan, Pranish Rajbanshi, Biplab Dakua, Vikas Kumar Dutta, Ankita Kumar, Anoop Roy, Mahendra Nath |
| author_facet | Ray, Samapika Roy, Niloy Barman, Biraj Kumar Karmakar, Paramita Bomzan, Pranish Rajbanshi, Biplab Dakua, Vikas Kumar Dutta, Ankita Kumar, Anoop Roy, Mahendra Nath |
| author_sort | Ray, Samapika |
| collection | PubMed |
| description | [Image: see text] Our present study intended to investigate the encapsulation of DL-AGT within the lipophilic cavity of a β-CD molecule. The consequential inclusion system was characterized by UV–visible spectroscopy and (1)H NMR, PXRD, SEM, and FT-IR studies. Molecular docking was performed for the inclusion complex to discover the most proper orientation, and it was seen that the drug DL-AGT fits into the cavity of β-CD in a 1:1 ratio, which was also confirmed from the Job plot. Furthermore, a comparison was done on the basis of cell viability between the drug and its inclusion complex. |
| format | Online Article Text |
| id | pubmed-8992260 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | American Chemical Society |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-89922602022-04-11 Synthesis and Characterization of an Inclusion Complex of dl-Aminoglutethimide with β-Cyclodextrin and Its Innovative Application in a Biological System: Computational and Experimental Investigations Ray, Samapika Roy, Niloy Barman, Biraj Kumar Karmakar, Paramita Bomzan, Pranish Rajbanshi, Biplab Dakua, Vikas Kumar Dutta, Ankita Kumar, Anoop Roy, Mahendra Nath ACS Omega [Image: see text] Our present study intended to investigate the encapsulation of DL-AGT within the lipophilic cavity of a β-CD molecule. The consequential inclusion system was characterized by UV–visible spectroscopy and (1)H NMR, PXRD, SEM, and FT-IR studies. Molecular docking was performed for the inclusion complex to discover the most proper orientation, and it was seen that the drug DL-AGT fits into the cavity of β-CD in a 1:1 ratio, which was also confirmed from the Job plot. Furthermore, a comparison was done on the basis of cell viability between the drug and its inclusion complex. American Chemical Society 2022-03-28 /pmc/articles/PMC8992260/ /pubmed/35415366 http://dx.doi.org/10.1021/acsomega.2c00011 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
| spellingShingle | Ray, Samapika Roy, Niloy Barman, Biraj Kumar Karmakar, Paramita Bomzan, Pranish Rajbanshi, Biplab Dakua, Vikas Kumar Dutta, Ankita Kumar, Anoop Roy, Mahendra Nath Synthesis and Characterization of an Inclusion Complex of dl-Aminoglutethimide with β-Cyclodextrin and Its Innovative Application in a Biological System: Computational and Experimental Investigations |
| title | Synthesis and Characterization of an Inclusion Complex
of dl-Aminoglutethimide with β-Cyclodextrin
and Its Innovative Application in a Biological System: Computational
and Experimental Investigations |
| title_full | Synthesis and Characterization of an Inclusion Complex
of dl-Aminoglutethimide with β-Cyclodextrin
and Its Innovative Application in a Biological System: Computational
and Experimental Investigations |
| title_fullStr | Synthesis and Characterization of an Inclusion Complex
of dl-Aminoglutethimide with β-Cyclodextrin
and Its Innovative Application in a Biological System: Computational
and Experimental Investigations |
| title_full_unstemmed | Synthesis and Characterization of an Inclusion Complex
of dl-Aminoglutethimide with β-Cyclodextrin
and Its Innovative Application in a Biological System: Computational
and Experimental Investigations |
| title_short | Synthesis and Characterization of an Inclusion Complex
of dl-Aminoglutethimide with β-Cyclodextrin
and Its Innovative Application in a Biological System: Computational
and Experimental Investigations |
| title_sort | synthesis and characterization of an inclusion complex
of dl-aminoglutethimide with β-cyclodextrin
and its innovative application in a biological system: computational
and experimental investigations |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8992260/ https://www.ncbi.nlm.nih.gov/pubmed/35415366 http://dx.doi.org/10.1021/acsomega.2c00011 |
| work_keys_str_mv | AT raysamapika synthesisandcharacterizationofaninclusioncomplexofdlaminoglutethimidewithbcyclodextrinanditsinnovativeapplicationinabiologicalsystemcomputationalandexperimentalinvestigations AT royniloy synthesisandcharacterizationofaninclusioncomplexofdlaminoglutethimidewithbcyclodextrinanditsinnovativeapplicationinabiologicalsystemcomputationalandexperimentalinvestigations AT barmanbirajkumar synthesisandcharacterizationofaninclusioncomplexofdlaminoglutethimidewithbcyclodextrinanditsinnovativeapplicationinabiologicalsystemcomputationalandexperimentalinvestigations AT karmakarparamita synthesisandcharacterizationofaninclusioncomplexofdlaminoglutethimidewithbcyclodextrinanditsinnovativeapplicationinabiologicalsystemcomputationalandexperimentalinvestigations AT bomzanpranish synthesisandcharacterizationofaninclusioncomplexofdlaminoglutethimidewithbcyclodextrinanditsinnovativeapplicationinabiologicalsystemcomputationalandexperimentalinvestigations AT rajbanshibiplab synthesisandcharacterizationofaninclusioncomplexofdlaminoglutethimidewithbcyclodextrinanditsinnovativeapplicationinabiologicalsystemcomputationalandexperimentalinvestigations AT dakuavikaskumar synthesisandcharacterizationofaninclusioncomplexofdlaminoglutethimidewithbcyclodextrinanditsinnovativeapplicationinabiologicalsystemcomputationalandexperimentalinvestigations AT duttaankita synthesisandcharacterizationofaninclusioncomplexofdlaminoglutethimidewithbcyclodextrinanditsinnovativeapplicationinabiologicalsystemcomputationalandexperimentalinvestigations AT kumaranoop synthesisandcharacterizationofaninclusioncomplexofdlaminoglutethimidewithbcyclodextrinanditsinnovativeapplicationinabiologicalsystemcomputationalandexperimentalinvestigations AT roymahendranath synthesisandcharacterizationofaninclusioncomplexofdlaminoglutethimidewithbcyclodextrinanditsinnovativeapplicationinabiologicalsystemcomputationalandexperimentalinvestigations |