Cargando…
Temporal trends in COVID-19 outcomes in people with rheumatic diseases in Ireland: data from the COVID-19 Global Rheumatology Alliance registry
OBJECTIVES: Although evidence is accumulating globally, data on outcomes in rheumatic disease and COVID-19 in Ireland are limited. We used data from the COVID-19 Global Rheumatology Alliance (C19-GRA) to describe time-varying COVID-19 outcomes for people with rheumatic disease in Ireland. METHODS: D...
Autores principales: | , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8992296/ https://www.ncbi.nlm.nih.gov/pubmed/35258593 http://dx.doi.org/10.1093/rheumatology/keac142 |
_version_ | 1784683706254884864 |
---|---|
author | Conway, Richard Nikiphorou, Elena Demetriou, Christiana A Low, Candice Leamy, Kelly Ryan, John G Kavanagh, Ronan Fraser, Alexander D Carey, John J O’Connell, Paul Flood, Rachael M Mullan, Ronan H Kane, David J Ambrose, Nicola Stafford, Frances Robinson, Philip C Liew, Jean W Grainger, Rebecca McCarthy, Geraldine M |
author_facet | Conway, Richard Nikiphorou, Elena Demetriou, Christiana A Low, Candice Leamy, Kelly Ryan, John G Kavanagh, Ronan Fraser, Alexander D Carey, John J O’Connell, Paul Flood, Rachael M Mullan, Ronan H Kane, David J Ambrose, Nicola Stafford, Frances Robinson, Philip C Liew, Jean W Grainger, Rebecca McCarthy, Geraldine M |
author_sort | Conway, Richard |
collection | PubMed |
description | OBJECTIVES: Although evidence is accumulating globally, data on outcomes in rheumatic disease and COVID-19 in Ireland are limited. We used data from the COVID-19 Global Rheumatology Alliance (C19-GRA) to describe time-varying COVID-19 outcomes for people with rheumatic disease in Ireland. METHODS: Data entered into the C19-GRA provider registry from Ireland between 24 March 2020 and 9 July 2021 were analysed. Differences in the likelihood of hospitalization and mortality according to demographic and clinical variables were investigated using Chi-squared test or Fisher’s exact test, as appropriate. Trends in odds of hospitalization and mortality over time were investigated using logistic regression with the time period as a categorical variable. RESULTS: Of 212 cases included, 59.4% were female and median age was 58.0 years (range 13–96). Of the 212 cases, 92 (43%) were hospitalized and 22 (10.4%) died. Increasing age, a diagnosis of gout, ever smoking, glucocorticoid use, having comorbidities and specific comorbidities of cancer, cardiovascular and pulmonary disease were more common in those hospitalized. A diagnosis of inflammatory arthritis, csDMARD and/or b/tsDMARD use were less frequent in those hospitalized. Increasing age, a diagnosis of gout, ever smoking, having comorbidities and specific comorbidities of obesity, cardiovascular and pulmonary disease were more common in those who died. Odds of hospitalization or mortality did not change over time. CONCLUSION: No temporal trend was observed in either COVID-19-related hospitalization or mortality outcomes for people with rheumatic disease in Ireland. |
format | Online Article Text |
id | pubmed-8992296 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-89922962022-04-12 Temporal trends in COVID-19 outcomes in people with rheumatic diseases in Ireland: data from the COVID-19 Global Rheumatology Alliance registry Conway, Richard Nikiphorou, Elena Demetriou, Christiana A Low, Candice Leamy, Kelly Ryan, John G Kavanagh, Ronan Fraser, Alexander D Carey, John J O’Connell, Paul Flood, Rachael M Mullan, Ronan H Kane, David J Ambrose, Nicola Stafford, Frances Robinson, Philip C Liew, Jean W Grainger, Rebecca McCarthy, Geraldine M Rheumatology (Oxford) Clinical Science OBJECTIVES: Although evidence is accumulating globally, data on outcomes in rheumatic disease and COVID-19 in Ireland are limited. We used data from the COVID-19 Global Rheumatology Alliance (C19-GRA) to describe time-varying COVID-19 outcomes for people with rheumatic disease in Ireland. METHODS: Data entered into the C19-GRA provider registry from Ireland between 24 March 2020 and 9 July 2021 were analysed. Differences in the likelihood of hospitalization and mortality according to demographic and clinical variables were investigated using Chi-squared test or Fisher’s exact test, as appropriate. Trends in odds of hospitalization and mortality over time were investigated using logistic regression with the time period as a categorical variable. RESULTS: Of 212 cases included, 59.4% were female and median age was 58.0 years (range 13–96). Of the 212 cases, 92 (43%) were hospitalized and 22 (10.4%) died. Increasing age, a diagnosis of gout, ever smoking, glucocorticoid use, having comorbidities and specific comorbidities of cancer, cardiovascular and pulmonary disease were more common in those hospitalized. A diagnosis of inflammatory arthritis, csDMARD and/or b/tsDMARD use were less frequent in those hospitalized. Increasing age, a diagnosis of gout, ever smoking, having comorbidities and specific comorbidities of obesity, cardiovascular and pulmonary disease were more common in those who died. Odds of hospitalization or mortality did not change over time. CONCLUSION: No temporal trend was observed in either COVID-19-related hospitalization or mortality outcomes for people with rheumatic disease in Ireland. Oxford University Press 2022-03-08 /pmc/articles/PMC8992296/ /pubmed/35258593 http://dx.doi.org/10.1093/rheumatology/keac142 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of the British Society for Rheumatology. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Clinical Science Conway, Richard Nikiphorou, Elena Demetriou, Christiana A Low, Candice Leamy, Kelly Ryan, John G Kavanagh, Ronan Fraser, Alexander D Carey, John J O’Connell, Paul Flood, Rachael M Mullan, Ronan H Kane, David J Ambrose, Nicola Stafford, Frances Robinson, Philip C Liew, Jean W Grainger, Rebecca McCarthy, Geraldine M Temporal trends in COVID-19 outcomes in people with rheumatic diseases in Ireland: data from the COVID-19 Global Rheumatology Alliance registry |
title | Temporal trends in COVID-19 outcomes in people with rheumatic diseases in Ireland: data from the COVID-19 Global Rheumatology Alliance registry |
title_full | Temporal trends in COVID-19 outcomes in people with rheumatic diseases in Ireland: data from the COVID-19 Global Rheumatology Alliance registry |
title_fullStr | Temporal trends in COVID-19 outcomes in people with rheumatic diseases in Ireland: data from the COVID-19 Global Rheumatology Alliance registry |
title_full_unstemmed | Temporal trends in COVID-19 outcomes in people with rheumatic diseases in Ireland: data from the COVID-19 Global Rheumatology Alliance registry |
title_short | Temporal trends in COVID-19 outcomes in people with rheumatic diseases in Ireland: data from the COVID-19 Global Rheumatology Alliance registry |
title_sort | temporal trends in covid-19 outcomes in people with rheumatic diseases in ireland: data from the covid-19 global rheumatology alliance registry |
topic | Clinical Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8992296/ https://www.ncbi.nlm.nih.gov/pubmed/35258593 http://dx.doi.org/10.1093/rheumatology/keac142 |
work_keys_str_mv | AT conwayrichard temporaltrendsincovid19outcomesinpeoplewithrheumaticdiseasesinirelanddatafromthecovid19globalrheumatologyallianceregistry AT nikiphorouelena temporaltrendsincovid19outcomesinpeoplewithrheumaticdiseasesinirelanddatafromthecovid19globalrheumatologyallianceregistry AT demetriouchristianaa temporaltrendsincovid19outcomesinpeoplewithrheumaticdiseasesinirelanddatafromthecovid19globalrheumatologyallianceregistry AT lowcandice temporaltrendsincovid19outcomesinpeoplewithrheumaticdiseasesinirelanddatafromthecovid19globalrheumatologyallianceregistry AT leamykelly temporaltrendsincovid19outcomesinpeoplewithrheumaticdiseasesinirelanddatafromthecovid19globalrheumatologyallianceregistry AT ryanjohng temporaltrendsincovid19outcomesinpeoplewithrheumaticdiseasesinirelanddatafromthecovid19globalrheumatologyallianceregistry AT kavanaghronan temporaltrendsincovid19outcomesinpeoplewithrheumaticdiseasesinirelanddatafromthecovid19globalrheumatologyallianceregistry AT fraseralexanderd temporaltrendsincovid19outcomesinpeoplewithrheumaticdiseasesinirelanddatafromthecovid19globalrheumatologyallianceregistry AT careyjohnj temporaltrendsincovid19outcomesinpeoplewithrheumaticdiseasesinirelanddatafromthecovid19globalrheumatologyallianceregistry AT oconnellpaul temporaltrendsincovid19outcomesinpeoplewithrheumaticdiseasesinirelanddatafromthecovid19globalrheumatologyallianceregistry AT floodrachaelm temporaltrendsincovid19outcomesinpeoplewithrheumaticdiseasesinirelanddatafromthecovid19globalrheumatologyallianceregistry AT mullanronanh temporaltrendsincovid19outcomesinpeoplewithrheumaticdiseasesinirelanddatafromthecovid19globalrheumatologyallianceregistry AT kanedavidj temporaltrendsincovid19outcomesinpeoplewithrheumaticdiseasesinirelanddatafromthecovid19globalrheumatologyallianceregistry AT ambrosenicola temporaltrendsincovid19outcomesinpeoplewithrheumaticdiseasesinirelanddatafromthecovid19globalrheumatologyallianceregistry AT staffordfrances temporaltrendsincovid19outcomesinpeoplewithrheumaticdiseasesinirelanddatafromthecovid19globalrheumatologyallianceregistry AT robinsonphilipc temporaltrendsincovid19outcomesinpeoplewithrheumaticdiseasesinirelanddatafromthecovid19globalrheumatologyallianceregistry AT liewjeanw temporaltrendsincovid19outcomesinpeoplewithrheumaticdiseasesinirelanddatafromthecovid19globalrheumatologyallianceregistry AT graingerrebecca temporaltrendsincovid19outcomesinpeoplewithrheumaticdiseasesinirelanddatafromthecovid19globalrheumatologyallianceregistry AT mccarthygeraldinem temporaltrendsincovid19outcomesinpeoplewithrheumaticdiseasesinirelanddatafromthecovid19globalrheumatologyallianceregistry AT temporaltrendsincovid19outcomesinpeoplewithrheumaticdiseasesinirelanddatafromthecovid19globalrheumatologyallianceregistry |