Differential Severe Acute Respiratory Syndrome Coronavirus 2 Antibody Profiles After Allergic Reactions to Messenger RNA Coronavirus Disease 2019 Vaccine( )

Allergic symptoms after messenger RNA (mRNA) coronavirus disease 2019 (COVID-19) vaccines occur in up to 2% of recipients. Compared to nonallergic controls (n = 18), individuals with immediate allergic reactions to mRNA COVID-19 vaccines (n = 8) mounted lower immunoglobulin G(1) (IgG(1)) to multiple...

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Detalles Bibliográficos
Autores principales: Maron, Jenny S, Conroy, Michelle, Naranbai, Vivek, Samarakoon, Upeka, Motazedi, Tina, Farmer, Jocelyn R, Freeman, Esther, Banerji, Aleena, Bartsch, Yannic C, Gregory, David J, Poznansky, Mark C, Alter, Galit, Blumenthal, Kimberly G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8992327/
https://www.ncbi.nlm.nih.gov/pubmed/35325158
http://dx.doi.org/10.1093/infdis/jiac107
Descripción
Sumario:Allergic symptoms after messenger RNA (mRNA) coronavirus disease 2019 (COVID-19) vaccines occur in up to 2% of recipients. Compared to nonallergic controls (n = 18), individuals with immediate allergic reactions to mRNA COVID-19 vaccines (n = 8) mounted lower immunoglobulin G(1) (IgG(1)) to multiple antigenic targets in severe acute respiratory syndrome coronavirus 2 spike following vaccination, with significantly lower IgG(1) to full-length spike (P = .04). Individuals with immediate allergic reactions to mRNA COVID-19 vaccines bound Fcγ receptors similarly to nonallergic controls. Although there was a trend toward an overall reduction in opsonophagocytic function in individuals with immediate allergic reactions compared to nonallergic controls, allergic patients produced functional antibodies exhibiting a high ratio of opsonophagocytic function to IgG(1) titer.

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