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Toxoplasma gondii vaccine candidates: a concise review

Toxoplasma gondii is an obligate intracellular parasite that causes toxoplasmosis. It has been shown that the severity of symptoms depends on the functioning of the host immune system. Although T. gondii infection typically does not lead to severe disease in healthy people and after infection, it in...

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Autores principales: Mamaghani, Amirreza Javadi, Fathollahi, Anwar, Arab-Mazar, Zahra, kohansal, Kobra, Fathollahi, Matin, Spotin, Adel, Bashiri, Homayoon, Bozorgomid, Arezoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8992420/
https://www.ncbi.nlm.nih.gov/pubmed/35394635
http://dx.doi.org/10.1007/s11845-022-02998-9
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author Mamaghani, Amirreza Javadi
Fathollahi, Anwar
Arab-Mazar, Zahra
kohansal, Kobra
Fathollahi, Matin
Spotin, Adel
Bashiri, Homayoon
Bozorgomid, Arezoo
author_facet Mamaghani, Amirreza Javadi
Fathollahi, Anwar
Arab-Mazar, Zahra
kohansal, Kobra
Fathollahi, Matin
Spotin, Adel
Bashiri, Homayoon
Bozorgomid, Arezoo
author_sort Mamaghani, Amirreza Javadi
collection PubMed
description Toxoplasma gondii is an obligate intracellular parasite that causes toxoplasmosis. It has been shown that the severity of symptoms depends on the functioning of the host immune system. Although T. gondii infection typically does not lead to severe disease in healthy people and after infection, it induces a stable immunity, but it can contribute to severe and even lethal Toxoplasmosis in immunocompromised individuals (AIDS, bone marrow transplant and neoplasia). The antigens that have been proposed to be used in vaccine candidate in various studies include surface antigens and secretory excretions that have been synthesized and evaluated in different studies. In some studies, secretory antigens play an important role in stimulating the host immune response. Various antigens such as SAG, GRA, ROP, ROM, and MAG have been from different strains of T. gondii have been synthesized and their protective effects have been evaluated in animal models in different vaccine platforms including recombinant antigens, nanoparticles, and DNA vaccine. Four bibliographic databases including Science Direct, PubMed Central (PMC), Scopus, and Google Scholar were searched for articles published up to 2020.The current review article focuses on recent studies on the use and usefulness of recombinant antigens, nanoparticles, and DNA vaccines.
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spelling pubmed-89924202022-04-11 Toxoplasma gondii vaccine candidates: a concise review Mamaghani, Amirreza Javadi Fathollahi, Anwar Arab-Mazar, Zahra kohansal, Kobra Fathollahi, Matin Spotin, Adel Bashiri, Homayoon Bozorgomid, Arezoo Ir J Med Sci Review Article Toxoplasma gondii is an obligate intracellular parasite that causes toxoplasmosis. It has been shown that the severity of symptoms depends on the functioning of the host immune system. Although T. gondii infection typically does not lead to severe disease in healthy people and after infection, it induces a stable immunity, but it can contribute to severe and even lethal Toxoplasmosis in immunocompromised individuals (AIDS, bone marrow transplant and neoplasia). The antigens that have been proposed to be used in vaccine candidate in various studies include surface antigens and secretory excretions that have been synthesized and evaluated in different studies. In some studies, secretory antigens play an important role in stimulating the host immune response. Various antigens such as SAG, GRA, ROP, ROM, and MAG have been from different strains of T. gondii have been synthesized and their protective effects have been evaluated in animal models in different vaccine platforms including recombinant antigens, nanoparticles, and DNA vaccine. Four bibliographic databases including Science Direct, PubMed Central (PMC), Scopus, and Google Scholar were searched for articles published up to 2020.The current review article focuses on recent studies on the use and usefulness of recombinant antigens, nanoparticles, and DNA vaccines. Springer International Publishing 2022-04-08 2023 /pmc/articles/PMC8992420/ /pubmed/35394635 http://dx.doi.org/10.1007/s11845-022-02998-9 Text en © The Author(s), under exclusive licence to Royal Academy of Medicine in Ireland 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Review Article
Mamaghani, Amirreza Javadi
Fathollahi, Anwar
Arab-Mazar, Zahra
kohansal, Kobra
Fathollahi, Matin
Spotin, Adel
Bashiri, Homayoon
Bozorgomid, Arezoo
Toxoplasma gondii vaccine candidates: a concise review
title Toxoplasma gondii vaccine candidates: a concise review
title_full Toxoplasma gondii vaccine candidates: a concise review
title_fullStr Toxoplasma gondii vaccine candidates: a concise review
title_full_unstemmed Toxoplasma gondii vaccine candidates: a concise review
title_short Toxoplasma gondii vaccine candidates: a concise review
title_sort toxoplasma gondii vaccine candidates: a concise review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8992420/
https://www.ncbi.nlm.nih.gov/pubmed/35394635
http://dx.doi.org/10.1007/s11845-022-02998-9
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