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Targeting of PI3K/AKT signaling and DNA damage response in acute myeloid leukemia: a novel therapeutic strategy to boost chemotherapy response and overcome resistance

Resistance of cancer patients to DNA damaging radiation therapy and chemotherapy remains a major problem in the clinic. The current review discusses the molecular mechanisms of therapy resistance in acute myeloid leukemia (AML) conferred by cooperative chemotherapy-induced DNA damage response (DDR)...

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Detalles Bibliográficos
Autores principales:	Estruch, Montserrat, Vittori, Camilla, Montesinos, Teresa Muñoz, Reckzeh, Kristian, Theilgaard-Mönch, Kim
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	OAE Publishing Inc. 2021
Materias:	Mini Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8992442/ https://www.ncbi.nlm.nih.gov/pubmed/35582388 http://dx.doi.org/10.20517/cdr.2021.76

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