Long non-coding RNAs regulation of therapeutic resistance

Non-protein coding RNAs have emerged as a regulator of cell signaling and cancer progression through regulation of cell proliferation, metastatic burden, and cancer stem cell capacity. A subtype of non-protein coding RNA is long non-protein coding RNA (lncRNA). Besides their aforementioned roles in...

Descripción completa

Detalles Bibliográficos
Autores principales: Tsang, Susan, Patel, Tajhal, Yustein, Jason T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: OAE Publishing Inc. 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8992514/
https://www.ncbi.nlm.nih.gov/pubmed/35582574
http://dx.doi.org/10.20517/cdr.2019.58
_version_ 1784683744651640832
author Tsang, Susan
Patel, Tajhal
Yustein, Jason T.
author_facet Tsang, Susan
Patel, Tajhal
Yustein, Jason T.
author_sort Tsang, Susan
collection PubMed
description Non-protein coding RNAs have emerged as a regulator of cell signaling and cancer progression through regulation of cell proliferation, metastatic burden, and cancer stem cell capacity. A subtype of non-protein coding RNA is long non-protein coding RNA (lncRNA). Besides their aforementioned roles in cancer cell biology, dysregulation of lncRNAs contribute to resistance to therapeutic treatments. A couple of important therapeutic classes are chemotherapy and targeted/hormone therapies. This review highlights the variety of malignancies affected by lncRNA dysregulation and the underlying mechanism causing therapeutic resistance.
format Online
Article
Text
id pubmed-8992514
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher OAE Publishing Inc.
record_format MEDLINE/PubMed
spelling pubmed-89925142022-05-16 Long non-coding RNAs regulation of therapeutic resistance Tsang, Susan Patel, Tajhal Yustein, Jason T. Cancer Drug Resist Review Non-protein coding RNAs have emerged as a regulator of cell signaling and cancer progression through regulation of cell proliferation, metastatic burden, and cancer stem cell capacity. A subtype of non-protein coding RNA is long non-protein coding RNA (lncRNA). Besides their aforementioned roles in cancer cell biology, dysregulation of lncRNAs contribute to resistance to therapeutic treatments. A couple of important therapeutic classes are chemotherapy and targeted/hormone therapies. This review highlights the variety of malignancies affected by lncRNA dysregulation and the underlying mechanism causing therapeutic resistance. OAE Publishing Inc. 2019-09-19 /pmc/articles/PMC8992514/ /pubmed/35582574 http://dx.doi.org/10.20517/cdr.2019.58 Text en © The Author(s) 2019. https://creativecommons.org/licenses/by/4.0/© The Author(s) 2019. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Tsang, Susan
Patel, Tajhal
Yustein, Jason T.
Long non-coding RNAs regulation of therapeutic resistance
title Long non-coding RNAs regulation of therapeutic resistance
title_full Long non-coding RNAs regulation of therapeutic resistance
title_fullStr Long non-coding RNAs regulation of therapeutic resistance
title_full_unstemmed Long non-coding RNAs regulation of therapeutic resistance
title_short Long non-coding RNAs regulation of therapeutic resistance
title_sort long non-coding rnas regulation of therapeutic resistance
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8992514/
https://www.ncbi.nlm.nih.gov/pubmed/35582574
http://dx.doi.org/10.20517/cdr.2019.58
work_keys_str_mv AT tsangsusan longnoncodingrnasregulationoftherapeuticresistance
AT pateltajhal longnoncodingrnasregulationoftherapeuticresistance
AT yusteinjasont longnoncodingrnasregulationoftherapeuticresistance

Ejemplares similares