Targeting the “undruggable” RAS - new strategies - new hope?

K-RAS is the most frequently mutated oncogene in solid tumors, such as pancreatic, colon or lung cancer. The GTPase K-RAS can either be in an active (GTP-loaded) or inactive (GDP-loaded) form. In its active form K-RAS forwards signals from growth factors, cytokines or hormones to the nucleus, regula...

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Detalles Bibliográficos
Autores principales: Mörchen, Britta, Shkura, Oleksandr, Stoll, Raphael, Helfrich, Iris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: OAE Publishing Inc. 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8992515/
https://www.ncbi.nlm.nih.gov/pubmed/35582595
http://dx.doi.org/10.20517/cdr.2019.21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8992515/
https://www.ncbi.nlm.nih.gov/pubmed/35582595
http://dx.doi.org/10.20517/cdr.2019.21

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