ONECUT2 as a key mediator of androgen receptor-independent cell growth and neuroendocrine differentiation in castration-resistant prostate cancer

Despite androgen dependence in a majority of castration-resistant prostate cancers, some cancer cells are independent of androgen receptor (AR) function, a feature of heterogeneity in prostate cancer. One of the aggressive variants of prostate cancer that are AR independent is neuroendocrine prostat...

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Detalles Bibliográficos
Autores principales: Choi, WonSeok William, Boland, Julia L., Lin, Jianqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: OAE Publishing Inc. 2022
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8992592/
https://www.ncbi.nlm.nih.gov/pubmed/35582526
http://dx.doi.org/10.20517/cdr.2021.108
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author Choi, WonSeok William
Boland, Julia L.
Lin, Jianqing
author_facet Choi, WonSeok William
Boland, Julia L.
Lin, Jianqing
author_sort Choi, WonSeok William
collection PubMed
description Despite androgen dependence in a majority of castration-resistant prostate cancers, some cancer cells are independent of androgen receptor (AR) function, a feature of heterogeneity in prostate cancer. One of the aggressive variants of prostate cancer that are AR independent is neuroendocrine prostate cancer (NEPC). This manuscript will focus on the new finding of human one cut domain family member 2 (ONECUT2) transcription factor and its role in castration resistance, especially in NEPC.
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spelling pubmed-89925922022-05-16 ONECUT2 as a key mediator of androgen receptor-independent cell growth and neuroendocrine differentiation in castration-resistant prostate cancer Choi, WonSeok William Boland, Julia L. Lin, Jianqing Cancer Drug Resist Perspective Despite androgen dependence in a majority of castration-resistant prostate cancers, some cancer cells are independent of androgen receptor (AR) function, a feature of heterogeneity in prostate cancer. One of the aggressive variants of prostate cancer that are AR independent is neuroendocrine prostate cancer (NEPC). This manuscript will focus on the new finding of human one cut domain family member 2 (ONECUT2) transcription factor and its role in castration resistance, especially in NEPC. OAE Publishing Inc. 2022-02-08 /pmc/articles/PMC8992592/ /pubmed/35582526 http://dx.doi.org/10.20517/cdr.2021.108 Text en © The Author(s) 2022. https://creativecommons.org/licenses/by/4.0/© The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Perspective
Choi, WonSeok William
Boland, Julia L.
Lin, Jianqing
ONECUT2 as a key mediator of androgen receptor-independent cell growth and neuroendocrine differentiation in castration-resistant prostate cancer
title ONECUT2 as a key mediator of androgen receptor-independent cell growth and neuroendocrine differentiation in castration-resistant prostate cancer
title_full ONECUT2 as a key mediator of androgen receptor-independent cell growth and neuroendocrine differentiation in castration-resistant prostate cancer
title_fullStr ONECUT2 as a key mediator of androgen receptor-independent cell growth and neuroendocrine differentiation in castration-resistant prostate cancer
title_full_unstemmed ONECUT2 as a key mediator of androgen receptor-independent cell growth and neuroendocrine differentiation in castration-resistant prostate cancer
title_short ONECUT2 as a key mediator of androgen receptor-independent cell growth and neuroendocrine differentiation in castration-resistant prostate cancer
title_sort onecut2 as a key mediator of androgen receptor-independent cell growth and neuroendocrine differentiation in castration-resistant prostate cancer
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8992592/
https://www.ncbi.nlm.nih.gov/pubmed/35582526
http://dx.doi.org/10.20517/cdr.2021.108
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AT linjianqing onecut2asakeymediatorofandrogenreceptorindependentcellgrowthandneuroendocrinedifferentiationincastrationresistantprostatecancer

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