THE PROMISE AND CHALLENGE OF THERAPEUTIC GENOME EDITING

Genome editing, involving precise manipulation of cellular DNA sequences to alter cell fates and organism traits, offers the potential to both understand human genetics and cure genetic disease as never before. Scientific, technical and ethical aspects of employing CRISPR technology for therapeutic...

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Detalles Bibliográficos
Autor principal: Doudna, Jennifer A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8992613/
https://www.ncbi.nlm.nih.gov/pubmed/32051598
http://dx.doi.org/10.1038/s41586-020-1978-5
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author Doudna, Jennifer A.
author_facet Doudna, Jennifer A.
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description Genome editing, involving precise manipulation of cellular DNA sequences to alter cell fates and organism traits, offers the potential to both understand human genetics and cure genetic disease as never before. Scientific, technical and ethical aspects of employing CRISPR technology for therapeutic applications in humans are discussed, focusing on specific examples that highlight both opportunities and challenges. Genome editing is or will soon be in the clinic for several diseases, with more applications in the pipeline. The rapid pace of the field demands active efforts to ensure responsible use of this breakthrough technology to treat, cure and prevent genetic disease.
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spelling pubmed-89926132022-04-08 THE PROMISE AND CHALLENGE OF THERAPEUTIC GENOME EDITING Doudna, Jennifer A. Nature Article Genome editing, involving precise manipulation of cellular DNA sequences to alter cell fates and organism traits, offers the potential to both understand human genetics and cure genetic disease as never before. Scientific, technical and ethical aspects of employing CRISPR technology for therapeutic applications in humans are discussed, focusing on specific examples that highlight both opportunities and challenges. Genome editing is or will soon be in the clinic for several diseases, with more applications in the pipeline. The rapid pace of the field demands active efforts to ensure responsible use of this breakthrough technology to treat, cure and prevent genetic disease. 2020-02 2020-02-12 /pmc/articles/PMC8992613/ /pubmed/32051598 http://dx.doi.org/10.1038/s41586-020-1978-5 Text en https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License, which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use.
spellingShingle Article
Doudna, Jennifer A.
THE PROMISE AND CHALLENGE OF THERAPEUTIC GENOME EDITING
title THE PROMISE AND CHALLENGE OF THERAPEUTIC GENOME EDITING
title_full THE PROMISE AND CHALLENGE OF THERAPEUTIC GENOME EDITING
title_fullStr THE PROMISE AND CHALLENGE OF THERAPEUTIC GENOME EDITING
title_full_unstemmed THE PROMISE AND CHALLENGE OF THERAPEUTIC GENOME EDITING
title_short THE PROMISE AND CHALLENGE OF THERAPEUTIC GENOME EDITING
title_sort promise and challenge of therapeutic genome editing
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8992613/
https://www.ncbi.nlm.nih.gov/pubmed/32051598
http://dx.doi.org/10.1038/s41586-020-1978-5
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