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Evaluation of radiation dose to pediatric models from whole body PET/CT imaging

Positron emission tomography (PET)/computed tomography (CT) is a well‐known modality for the diagnosis of various diseases in children and adult patients. On the other hand, younger patients are more radiosensitive than adults, so there are concerns about the level of ionizing radiation exposure in...

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Autores principales: Mohammadi, Najmeh, Akhlaghi, Parisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8992961/
https://www.ncbi.nlm.nih.gov/pubmed/35112453
http://dx.doi.org/10.1002/acm2.13545
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author Mohammadi, Najmeh
Akhlaghi, Parisa
author_facet Mohammadi, Najmeh
Akhlaghi, Parisa
author_sort Mohammadi, Najmeh
collection PubMed
description Positron emission tomography (PET)/computed tomography (CT) is a well‐known modality for the diagnosis of various diseases in children and adult patients. On the other hand, younger patients are more radiosensitive than adults, so there are concerns about the level of ionizing radiation exposure in pediatric whole body PET/CT imaging. In this regard, comprehensive specific radiation dosimetry for whole body PET/CT imaging is highly desired for different ages, sizes, and shapes. Therefore, in this study, organ absorbed doses were evaluated for pediatric voxel models from 4 to 14 years old and compared with those of ICRP phantoms. Monte Carlo calculation was performed to evaluate S‐value, absorbed dose, and effective dose from (18)F‐FDG radiotracers and whole body CT scan for different computational models, including 4‐ to 14‐year‐old phantoms. The results showed that the S‐value and, therefore, absorbed dose of (18)F‐FDG strongly depended on the phantom anatomy. These variations were justified by the distance between source and target organs. Moreover, on average, the absorbed doses from whole body CT scans were 13.5 times lower than those from (18)F‐FDG for all organs. According to the results, various anatomies and ages should be considered for accurate dose evaluation. These data can be used for specific risk assessment of the pediatric population in clinical nuclear imaging.
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spelling pubmed-89929612022-04-13 Evaluation of radiation dose to pediatric models from whole body PET/CT imaging Mohammadi, Najmeh Akhlaghi, Parisa J Appl Clin Med Phys Medical Imaging Positron emission tomography (PET)/computed tomography (CT) is a well‐known modality for the diagnosis of various diseases in children and adult patients. On the other hand, younger patients are more radiosensitive than adults, so there are concerns about the level of ionizing radiation exposure in pediatric whole body PET/CT imaging. In this regard, comprehensive specific radiation dosimetry for whole body PET/CT imaging is highly desired for different ages, sizes, and shapes. Therefore, in this study, organ absorbed doses were evaluated for pediatric voxel models from 4 to 14 years old and compared with those of ICRP phantoms. Monte Carlo calculation was performed to evaluate S‐value, absorbed dose, and effective dose from (18)F‐FDG radiotracers and whole body CT scan for different computational models, including 4‐ to 14‐year‐old phantoms. The results showed that the S‐value and, therefore, absorbed dose of (18)F‐FDG strongly depended on the phantom anatomy. These variations were justified by the distance between source and target organs. Moreover, on average, the absorbed doses from whole body CT scans were 13.5 times lower than those from (18)F‐FDG for all organs. According to the results, various anatomies and ages should be considered for accurate dose evaluation. These data can be used for specific risk assessment of the pediatric population in clinical nuclear imaging. John Wiley and Sons Inc. 2022-02-02 /pmc/articles/PMC8992961/ /pubmed/35112453 http://dx.doi.org/10.1002/acm2.13545 Text en © 2022 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, LLC on behalf of The American Association of Physicists in Medicine https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Medical Imaging
Mohammadi, Najmeh
Akhlaghi, Parisa
Evaluation of radiation dose to pediatric models from whole body PET/CT imaging
title Evaluation of radiation dose to pediatric models from whole body PET/CT imaging
title_full Evaluation of radiation dose to pediatric models from whole body PET/CT imaging
title_fullStr Evaluation of radiation dose to pediatric models from whole body PET/CT imaging
title_full_unstemmed Evaluation of radiation dose to pediatric models from whole body PET/CT imaging
title_short Evaluation of radiation dose to pediatric models from whole body PET/CT imaging
title_sort evaluation of radiation dose to pediatric models from whole body pet/ct imaging
topic Medical Imaging
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8992961/
https://www.ncbi.nlm.nih.gov/pubmed/35112453
http://dx.doi.org/10.1002/acm2.13545
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