Dose Addition in the Induction of Craniofacial Malformations in Zebrafish Embryos Exposed to a Complex Mixture of Food-Relevant Chemicals with Dissimilar Modes of Action

BACKGROUND: Humans are exposed to combinations of chemicals. In cumulative risk assessment (CRA), regulatory bodies such as the European Food Safety Authority consider dose addition as a default and sufficiently conservative approach. The principle of dose addition was confirmed previously for induc...

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Detalles Bibliográficos
Autores principales: Van Der Ven, Leo T.M., Van Ommeren, Paul, Zwart, Edwin P., Gremmer, Eric R., Hodemaekers, Hennie M., Heusinkveld, Harm J., van Klaveren, Jacob D., Rorije, Emiel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Environmental Health Perspectives 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8992969/
https://www.ncbi.nlm.nih.gov/pubmed/35394809
http://dx.doi.org/10.1289/EHP9888

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