Development of mAb-based polyglutamine-dependent and polyglutamine length-independent huntingtin quantification assays with cross-site validation

Huntington’s disease (HD) is caused by an expansion of the CAG trinucleotide repeat domain in the huntingtin gene that results in expression of a mutant huntingtin protein (mHTT) containing an expanded polyglutamine tract in the amino terminus. A number of therapeutic approaches that aim to reduce m...

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Detalles Bibliográficos
Autores principales: Fischer, David F., Dijkstra, Sipke, Lo, Kimberly, Suijker, Johnny, Correia, Ana C. P., Naud, Patricia, Poirier, Martin, Tessari, Michela A., Boogaard, Ivette, Flynn, Geraldine, Visser, Mijke, Lamers, Marieke B. A. C., McAllister, George, Munoz-Sanjuan, Ignacio, Macdonald, Douglas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8992994/
https://www.ncbi.nlm.nih.gov/pubmed/35395060
http://dx.doi.org/10.1371/journal.pone.0266812

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