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Discovery of novel benzophenone integrated derivatives as anti-Alzheimer’s agents targeting presenilin-1 and presenilin-2 inhibition: A computational approach

The most commonly accepted hypothesis of Alzheimer’s disease (AD) is the amyloid hypothesis caused due to formation of accumulation of Aβ42 isoform, which leads to neurodegeneration. In this regard, presenilin-1 (PSEN-1) and -2 (PSEN-2) proteins play a crucial role by altering the amyloid precursor...

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Detalles Bibliográficos
Autores principales:	Martiz, Reshma Mary, Patil, Shashank M., Ramu, Ramith, M. K., Jayanthi, P., Ashwini, Ranganatha, Lakshmi V., Khanum, Shaukath Ara, Silina, Ekaterina, Stupin, Victor, Achar, Raghu Ram
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8993008/ https://www.ncbi.nlm.nih.gov/pubmed/35395008 http://dx.doi.org/10.1371/journal.pone.0265022

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