Modeled impact of the COVID-19 pandemic and associated reduction in adult vaccinations on herpes zoster in the United States

Due to COVID-19, vaccinations dropped in 2020 and 2021. We estimated the impact of reduced recombinant zoster vaccine (RZV) use on herpes zoster (HZ) cases, complications, and quality-adjusted life-year (QALY) losses among older adults. Various scenarios were compared with Markov models using data f...

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Autores principales: Curran, Desmond, La, Elizabeth M., Salem, Ahmed, Singer, David, Lecrenier, Nicolas, Poston, Sara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Coronavirus – Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8993052/
https://www.ncbi.nlm.nih.gov/pubmed/35049412
http://dx.doi.org/10.1080/21645515.2022.2027196
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author Curran, Desmond
La, Elizabeth M.
Salem, Ahmed
Singer, David
Lecrenier, Nicolas
Poston, Sara
author_facet Curran, Desmond
La, Elizabeth M.
Salem, Ahmed
Singer, David
Lecrenier, Nicolas
Poston, Sara
author_sort Curran, Desmond
collection PubMed
description Due to COVID-19, vaccinations dropped in 2020 and 2021. We estimated the impact of reduced recombinant zoster vaccine (RZV) use on herpes zoster (HZ) cases, complications, and quality-adjusted life-year (QALY) losses among older adults. Various scenarios were compared with Markov models using data from national sources, clinical trials, and literature. Missed series initiations were calculated based on RZV distributed doses. In 2020, 3.9 million RZV series initiations were missed, resulting in 31,945 HZ cases, 2,714 postherpetic neuralgia cases, and 610 lost QALYs. Scenarios further projected disease burden increases if individuals remain unvaccinated in 2021 or the same number of initiations are missed in 2021. Health professionals should emphasize the importance of vaccination against all preventable diseases during the COVID-19 era.
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spelling pubmed-89930522022-04-09 Modeled impact of the COVID-19 pandemic and associated reduction in adult vaccinations on herpes zoster in the United States Curran, Desmond La, Elizabeth M. Salem, Ahmed Singer, David Lecrenier, Nicolas Poston, Sara Hum Vaccin Immunother Coronavirus – Short Report Due to COVID-19, vaccinations dropped in 2020 and 2021. We estimated the impact of reduced recombinant zoster vaccine (RZV) use on herpes zoster (HZ) cases, complications, and quality-adjusted life-year (QALY) losses among older adults. Various scenarios were compared with Markov models using data from national sources, clinical trials, and literature. Missed series initiations were calculated based on RZV distributed doses. In 2020, 3.9 million RZV series initiations were missed, resulting in 31,945 HZ cases, 2,714 postherpetic neuralgia cases, and 610 lost QALYs. Scenarios further projected disease burden increases if individuals remain unvaccinated in 2021 or the same number of initiations are missed in 2021. Health professionals should emphasize the importance of vaccination against all preventable diseases during the COVID-19 era. Taylor & Francis 2022-01-20 /pmc/articles/PMC8993052/ /pubmed/35049412 http://dx.doi.org/10.1080/21645515.2022.2027196 Text en © 2022 GlaxoSmithKline Biologicals S.A. Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Coronavirus – Short Report
Curran, Desmond
La, Elizabeth M.
Salem, Ahmed
Singer, David
Lecrenier, Nicolas
Poston, Sara
Modeled impact of the COVID-19 pandemic and associated reduction in adult vaccinations on herpes zoster in the United States
title Modeled impact of the COVID-19 pandemic and associated reduction in adult vaccinations on herpes zoster in the United States
title_full Modeled impact of the COVID-19 pandemic and associated reduction in adult vaccinations on herpes zoster in the United States
title_fullStr Modeled impact of the COVID-19 pandemic and associated reduction in adult vaccinations on herpes zoster in the United States
title_full_unstemmed Modeled impact of the COVID-19 pandemic and associated reduction in adult vaccinations on herpes zoster in the United States
title_short Modeled impact of the COVID-19 pandemic and associated reduction in adult vaccinations on herpes zoster in the United States
title_sort modeled impact of the covid-19 pandemic and associated reduction in adult vaccinations on herpes zoster in the united states
topic Coronavirus – Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8993052/
https://www.ncbi.nlm.nih.gov/pubmed/35049412
http://dx.doi.org/10.1080/21645515.2022.2027196
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