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Variations in Aspects of Neural Precursor Cell Neurogenesis in a Human Model of HSV-1 Infection
Encephalitis, the most significant of the central nervous system (CNS) diseases caused by Herpes simplex virus 1 (HSV-1), may have long-term sequelae in survivors treated with acyclovir, the cause of which is unclear. HSV-1 exhibits a tropism toward neurogenic niches in CNS enriched with neural prec...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8993067/ https://www.ncbi.nlm.nih.gov/pubmed/35384798 http://dx.doi.org/10.1080/15476278.2022.2055354 |
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author | Zheng, Wenxiao Benner, Emily M. Bloom, David C. Muralidaran, Vaishali Caldwell, Jill K. Prabhudesai, Anuya Piazza, Paolo A. Wood, Joel Kinchington, Paul R. Nimgaonkar, Vishwajit L. D’Aiuto, Leonardo |
author_facet | Zheng, Wenxiao Benner, Emily M. Bloom, David C. Muralidaran, Vaishali Caldwell, Jill K. Prabhudesai, Anuya Piazza, Paolo A. Wood, Joel Kinchington, Paul R. Nimgaonkar, Vishwajit L. D’Aiuto, Leonardo |
author_sort | Zheng, Wenxiao |
collection | PubMed |
description | Encephalitis, the most significant of the central nervous system (CNS) diseases caused by Herpes simplex virus 1 (HSV-1), may have long-term sequelae in survivors treated with acyclovir, the cause of which is unclear. HSV-1 exhibits a tropism toward neurogenic niches in CNS enriched with neural precursor cells (NPCs), which play a pivotal role in neurogenesis. NPCs are susceptible to HSV-1. There is a paucity of information regarding the influence of HSV-1 on neurogenesis in humans. We investigated HSV-1 infection of NPCs from two individuals. Our results show (i) HSV-1 impairs, to different extents, the proliferation, self-renewing, and, to an even greater extent, migration of NPCs from these two subjects; (ii) The protective effect of the gold-standard antiherpetic drug acyclovir (ACV) varies with viral dose and is incomplete. It is also subject to differences in terms of efficacy of the NPCs derived from these two individuals. These results suggest that the effects of HSV-1 may have on aspects of NPC neurogenesis may vary among individuals, even in the presence of acyclovir, and this may contribute to the heterogeneity of cognitive sequelae across encephalitis survivors. Further analysis of NPC cell lines from a larger number of individuals is warranted. |
format | Online Article Text |
id | pubmed-8993067 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-89930672022-04-09 Variations in Aspects of Neural Precursor Cell Neurogenesis in a Human Model of HSV-1 Infection Zheng, Wenxiao Benner, Emily M. Bloom, David C. Muralidaran, Vaishali Caldwell, Jill K. Prabhudesai, Anuya Piazza, Paolo A. Wood, Joel Kinchington, Paul R. Nimgaonkar, Vishwajit L. D’Aiuto, Leonardo Organogenesis Research Article Encephalitis, the most significant of the central nervous system (CNS) diseases caused by Herpes simplex virus 1 (HSV-1), may have long-term sequelae in survivors treated with acyclovir, the cause of which is unclear. HSV-1 exhibits a tropism toward neurogenic niches in CNS enriched with neural precursor cells (NPCs), which play a pivotal role in neurogenesis. NPCs are susceptible to HSV-1. There is a paucity of information regarding the influence of HSV-1 on neurogenesis in humans. We investigated HSV-1 infection of NPCs from two individuals. Our results show (i) HSV-1 impairs, to different extents, the proliferation, self-renewing, and, to an even greater extent, migration of NPCs from these two subjects; (ii) The protective effect of the gold-standard antiherpetic drug acyclovir (ACV) varies with viral dose and is incomplete. It is also subject to differences in terms of efficacy of the NPCs derived from these two individuals. These results suggest that the effects of HSV-1 may have on aspects of NPC neurogenesis may vary among individuals, even in the presence of acyclovir, and this may contribute to the heterogeneity of cognitive sequelae across encephalitis survivors. Further analysis of NPC cell lines from a larger number of individuals is warranted. Taylor & Francis 2022-04-06 /pmc/articles/PMC8993067/ /pubmed/35384798 http://dx.doi.org/10.1080/15476278.2022.2055354 Text en © 2022 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Zheng, Wenxiao Benner, Emily M. Bloom, David C. Muralidaran, Vaishali Caldwell, Jill K. Prabhudesai, Anuya Piazza, Paolo A. Wood, Joel Kinchington, Paul R. Nimgaonkar, Vishwajit L. D’Aiuto, Leonardo Variations in Aspects of Neural Precursor Cell Neurogenesis in a Human Model of HSV-1 Infection |
title | Variations in Aspects of Neural Precursor Cell Neurogenesis in a Human Model of HSV-1 Infection |
title_full | Variations in Aspects of Neural Precursor Cell Neurogenesis in a Human Model of HSV-1 Infection |
title_fullStr | Variations in Aspects of Neural Precursor Cell Neurogenesis in a Human Model of HSV-1 Infection |
title_full_unstemmed | Variations in Aspects of Neural Precursor Cell Neurogenesis in a Human Model of HSV-1 Infection |
title_short | Variations in Aspects of Neural Precursor Cell Neurogenesis in a Human Model of HSV-1 Infection |
title_sort | variations in aspects of neural precursor cell neurogenesis in a human model of hsv-1 infection |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8993067/ https://www.ncbi.nlm.nih.gov/pubmed/35384798 http://dx.doi.org/10.1080/15476278.2022.2055354 |
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