CXCL5-mediated accumulation of mature neutrophils in lung cancer tissues impairs the differentiation program of anticancer CD8 T cells and limits the efficacy of checkpoint inhibitors

Lung tumor-infiltrating neutrophils are known to support growth and dissemination of cancer cells and to suppress T cell responses. However, the precise impact of tissue neutrophils on programming and differentiation of anticancer CD8 T cells in vivo remains poorly understood. Here, we identified ca...

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Detalles Bibliográficos
Autores principales: Simoncello, Francesca, Piperno, Giulia Maria, Caronni, Nicoletta, Amadio, Roberto, Cappelletto, Ambra, Canarutto, Giulia, Piazza, Silvano, Bicciato, Silvio, Benvenuti, Federica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8993093/
https://www.ncbi.nlm.nih.gov/pubmed/35402081
http://dx.doi.org/10.1080/2162402X.2022.2059876

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