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The Mechanism of Acrylamide-Induced Neurotoxicity: Current Status and Future Perspectives

Acrylamide (ACR), a potential neurotoxin, is produced by the Maillard reaction between reducing sugars and free amino acids during food processing. Over the past decade, the neurotoxicity of ACR has caused increasing concern, prompting many related studies. This review summarized the relevant litera...

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Detalles Bibliográficos
Autores principales: Zhao, Mengyao, Zhang, Boya, Deng, Linlin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8993146/
https://www.ncbi.nlm.nih.gov/pubmed/35399689
http://dx.doi.org/10.3389/fnut.2022.859189
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author Zhao, Mengyao
Zhang, Boya
Deng, Linlin
author_facet Zhao, Mengyao
Zhang, Boya
Deng, Linlin
author_sort Zhao, Mengyao
collection PubMed
description Acrylamide (ACR), a potential neurotoxin, is produced by the Maillard reaction between reducing sugars and free amino acids during food processing. Over the past decade, the neurotoxicity of ACR has caused increasing concern, prompting many related studies. This review summarized the relevant literature published in recent years and discussed the exposure to occupational, environmental, and daily ACR contamination in food. Moreover, ACR metabolism and the potential mechanism of ACR-induced neurotoxicity were discussed, with particular focus on the axonal degeneration of the nervous system, nerve cell apoptosis, oxidative stress, inflammatory response, and gut-brain axis homeostasis. Additionally, the limitations of existing knowledge, as well as new perspectives, were examined, specifically regarding the connection between the neurotoxicity caused by ACR and neurodegenerative diseases, NOD-like receptor protein 3 (NLRP3) inflammasome-related neuroinflammation, and microbiota-gut-brain axis signaling. This review might provide systematic information for developing an alternative pathway approach to assess ACR risk.
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spelling pubmed-89931462022-04-09 The Mechanism of Acrylamide-Induced Neurotoxicity: Current Status and Future Perspectives Zhao, Mengyao Zhang, Boya Deng, Linlin Front Nutr Nutrition Acrylamide (ACR), a potential neurotoxin, is produced by the Maillard reaction between reducing sugars and free amino acids during food processing. Over the past decade, the neurotoxicity of ACR has caused increasing concern, prompting many related studies. This review summarized the relevant literature published in recent years and discussed the exposure to occupational, environmental, and daily ACR contamination in food. Moreover, ACR metabolism and the potential mechanism of ACR-induced neurotoxicity were discussed, with particular focus on the axonal degeneration of the nervous system, nerve cell apoptosis, oxidative stress, inflammatory response, and gut-brain axis homeostasis. Additionally, the limitations of existing knowledge, as well as new perspectives, were examined, specifically regarding the connection between the neurotoxicity caused by ACR and neurodegenerative diseases, NOD-like receptor protein 3 (NLRP3) inflammasome-related neuroinflammation, and microbiota-gut-brain axis signaling. This review might provide systematic information for developing an alternative pathway approach to assess ACR risk. Frontiers Media S.A. 2022-03-25 /pmc/articles/PMC8993146/ /pubmed/35399689 http://dx.doi.org/10.3389/fnut.2022.859189 Text en Copyright © 2022 Zhao, Zhang and Deng. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Zhao, Mengyao
Zhang, Boya
Deng, Linlin
The Mechanism of Acrylamide-Induced Neurotoxicity: Current Status and Future Perspectives
title The Mechanism of Acrylamide-Induced Neurotoxicity: Current Status and Future Perspectives
title_full The Mechanism of Acrylamide-Induced Neurotoxicity: Current Status and Future Perspectives
title_fullStr The Mechanism of Acrylamide-Induced Neurotoxicity: Current Status and Future Perspectives
title_full_unstemmed The Mechanism of Acrylamide-Induced Neurotoxicity: Current Status and Future Perspectives
title_short The Mechanism of Acrylamide-Induced Neurotoxicity: Current Status and Future Perspectives
title_sort mechanism of acrylamide-induced neurotoxicity: current status and future perspectives
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8993146/
https://www.ncbi.nlm.nih.gov/pubmed/35399689
http://dx.doi.org/10.3389/fnut.2022.859189
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