Acute Promyelocytic Leukemia in a Patient With Chronic Continuous Type of Crohn’s Disease

Chronic inflammation can induce leukemogenic mutations in hematopoietic stem cells (HSCs). We report a case of acute promyelocytic leukemia (APL) in a patient with chronic continuous type of Crohn’s disease. The patient had been diagnosed with Crohn’s disease at the age of 28 years and had received...

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Detalles Bibliográficos
Autores principales: Kinoshita, Shiori, Tanida, Satoshi, Kawai, Akimi, Shiraga, Kazuhide, Nakamura, Tomoyuki, Oiwa, Kana, Suzuki, Tomotaka, Ito, Asahi, Ri, Masaki, Kusumoto, Shigeru, Komatsu, Hirokazu, Iida, Shinsuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elmer Press 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8993430/
https://www.ncbi.nlm.nih.gov/pubmed/35464606
http://dx.doi.org/10.14740/jocmr4675
Descripción
Sumario:Chronic inflammation can induce leukemogenic mutations in hematopoietic stem cells (HSCs). We report a case of acute promyelocytic leukemia (APL) in a patient with chronic continuous type of Crohn’s disease. The patient had been diagnosed with Crohn’s disease at the age of 28 years and had received conventional treatments with biologics, but not azathioprine. At the age of 51, he was diagnosed with APL with ider(17). Long-term exposure to chronic continuous inflammation from Crohn’s disease might be a factor inducing genomic instability in HSCs, which lead to the subsequent development of APL. APL is a rare hematological manifestation that required attention in Crohn’s disease patients.

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