Acute Promyelocytic Leukemia in a Patient With Chronic Continuous Type of Crohn’s Disease

Chronic inflammation can induce leukemogenic mutations in hematopoietic stem cells (HSCs). We report a case of acute promyelocytic leukemia (APL) in a patient with chronic continuous type of Crohn’s disease. The patient had been diagnosed with Crohn’s disease at the age of 28 years and had received...

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Autores principales: Kinoshita, Shiori, Tanida, Satoshi, Kawai, Akimi, Shiraga, Kazuhide, Nakamura, Tomoyuki, Oiwa, Kana, Suzuki, Tomotaka, Ito, Asahi, Ri, Masaki, Kusumoto, Shigeru, Komatsu, Hirokazu, Iida, Shinsuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elmer Press 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8993430/
https://www.ncbi.nlm.nih.gov/pubmed/35464606
http://dx.doi.org/10.14740/jocmr4675
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author Kinoshita, Shiori
Tanida, Satoshi
Kawai, Akimi
Shiraga, Kazuhide
Nakamura, Tomoyuki
Oiwa, Kana
Suzuki, Tomotaka
Ito, Asahi
Ri, Masaki
Kusumoto, Shigeru
Komatsu, Hirokazu
Iida, Shinsuke
author_facet Kinoshita, Shiori
Tanida, Satoshi
Kawai, Akimi
Shiraga, Kazuhide
Nakamura, Tomoyuki
Oiwa, Kana
Suzuki, Tomotaka
Ito, Asahi
Ri, Masaki
Kusumoto, Shigeru
Komatsu, Hirokazu
Iida, Shinsuke
author_sort Kinoshita, Shiori
collection PubMed
description Chronic inflammation can induce leukemogenic mutations in hematopoietic stem cells (HSCs). We report a case of acute promyelocytic leukemia (APL) in a patient with chronic continuous type of Crohn’s disease. The patient had been diagnosed with Crohn’s disease at the age of 28 years and had received conventional treatments with biologics, but not azathioprine. At the age of 51, he was diagnosed with APL with ider(17). Long-term exposure to chronic continuous inflammation from Crohn’s disease might be a factor inducing genomic instability in HSCs, which lead to the subsequent development of APL. APL is a rare hematological manifestation that required attention in Crohn’s disease patients.
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spelling pubmed-89934302022-04-22 Acute Promyelocytic Leukemia in a Patient With Chronic Continuous Type of Crohn’s Disease Kinoshita, Shiori Tanida, Satoshi Kawai, Akimi Shiraga, Kazuhide Nakamura, Tomoyuki Oiwa, Kana Suzuki, Tomotaka Ito, Asahi Ri, Masaki Kusumoto, Shigeru Komatsu, Hirokazu Iida, Shinsuke J Clin Med Res Case Report Chronic inflammation can induce leukemogenic mutations in hematopoietic stem cells (HSCs). We report a case of acute promyelocytic leukemia (APL) in a patient with chronic continuous type of Crohn’s disease. The patient had been diagnosed with Crohn’s disease at the age of 28 years and had received conventional treatments with biologics, but not azathioprine. At the age of 51, he was diagnosed with APL with ider(17). Long-term exposure to chronic continuous inflammation from Crohn’s disease might be a factor inducing genomic instability in HSCs, which lead to the subsequent development of APL. APL is a rare hematological manifestation that required attention in Crohn’s disease patients. Elmer Press 2022-03 2022-03-25 /pmc/articles/PMC8993430/ /pubmed/35464606 http://dx.doi.org/10.14740/jocmr4675 Text en Copyright 2022, Kinoshita et al. https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution Non-Commercial 4.0 International License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Kinoshita, Shiori
Tanida, Satoshi
Kawai, Akimi
Shiraga, Kazuhide
Nakamura, Tomoyuki
Oiwa, Kana
Suzuki, Tomotaka
Ito, Asahi
Ri, Masaki
Kusumoto, Shigeru
Komatsu, Hirokazu
Iida, Shinsuke
Acute Promyelocytic Leukemia in a Patient With Chronic Continuous Type of Crohn’s Disease
title Acute Promyelocytic Leukemia in a Patient With Chronic Continuous Type of Crohn’s Disease
title_full Acute Promyelocytic Leukemia in a Patient With Chronic Continuous Type of Crohn’s Disease
title_fullStr Acute Promyelocytic Leukemia in a Patient With Chronic Continuous Type of Crohn’s Disease
title_full_unstemmed Acute Promyelocytic Leukemia in a Patient With Chronic Continuous Type of Crohn’s Disease
title_short Acute Promyelocytic Leukemia in a Patient With Chronic Continuous Type of Crohn’s Disease
title_sort acute promyelocytic leukemia in a patient with chronic continuous type of crohn’s disease
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8993430/
https://www.ncbi.nlm.nih.gov/pubmed/35464606
http://dx.doi.org/10.14740/jocmr4675
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