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Relationship Between ABO Blood Group and the Risk of Colorectal Cancer: A Retrospective Multicenter Study

BACKGROUND: Colorectal cancer (CRC) is the fourth deadliest cancer, with approximately 900,000 deaths annually. CRC is a multifactorial disease in which a set of factors, including environmental, hereditary, and genetic factors, are integrated into cancer development. Studies have suggested an assoc...

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Autores principales: Al-Sawat, Abdullah, Alswat, Shrooq, Alosaimi, Rasha, Alharthi, Mohammed, Alsuwat, Mohammed, Alhasani, Kholoud, Alharthi, Walaa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elmer Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8993432/
https://www.ncbi.nlm.nih.gov/pubmed/35464604
http://dx.doi.org/10.14740/jocmr4691
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author Al-Sawat, Abdullah
Alswat, Shrooq
Alosaimi, Rasha
Alharthi, Mohammed
Alsuwat, Mohammed
Alhasani, Kholoud
Alharthi, Walaa
author_facet Al-Sawat, Abdullah
Alswat, Shrooq
Alosaimi, Rasha
Alharthi, Mohammed
Alsuwat, Mohammed
Alhasani, Kholoud
Alharthi, Walaa
author_sort Al-Sawat, Abdullah
collection PubMed
description BACKGROUND: Colorectal cancer (CRC) is the fourth deadliest cancer, with approximately 900,000 deaths annually. CRC is a multifactorial disease in which a set of factors, including environmental, hereditary, and genetic factors, are integrated into cancer development. Studies have suggested an association between hereditary antigens in the human blood group system and the risk of different cancers. This study aimed to evaluate the relationship between blood groups and CRC risk. METHODS: A record-based retrospective study was performed between January 2017 and August 2021. This study targeted patients diagnosed with CRC during the study period. Data of patients who agreed to participate were collected using a pre-structured checklist. The extracted data included patients’ demographic blood groups and risk factors, including history of inflammatory bowel disease or CRC. RESULTS: A total of 199 patients, aged 22 to 96 years (mean age: 61.6 ± 14.7 years), were included. The blood groups of 101 (50.8%), 59 (29.6%), 26 (13.1%), and 13 (6.5%) patients were O, A, B, and AB, respectively. Colon cancer was the most frequently reported cancer (155/199, 77.9%) across all blood groups and showed the highest frequency among patients with blood group O (74/155, 47.7%), without statistical significance (P = 0.111). CONCLUSION: Our study showed a statistically significant relationship between AB and non-O blood types and colon cancer compared to the O blood group.
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spelling pubmed-89934322022-04-22 Relationship Between ABO Blood Group and the Risk of Colorectal Cancer: A Retrospective Multicenter Study Al-Sawat, Abdullah Alswat, Shrooq Alosaimi, Rasha Alharthi, Mohammed Alsuwat, Mohammed Alhasani, Kholoud Alharthi, Walaa J Clin Med Res Original Article BACKGROUND: Colorectal cancer (CRC) is the fourth deadliest cancer, with approximately 900,000 deaths annually. CRC is a multifactorial disease in which a set of factors, including environmental, hereditary, and genetic factors, are integrated into cancer development. Studies have suggested an association between hereditary antigens in the human blood group system and the risk of different cancers. This study aimed to evaluate the relationship between blood groups and CRC risk. METHODS: A record-based retrospective study was performed between January 2017 and August 2021. This study targeted patients diagnosed with CRC during the study period. Data of patients who agreed to participate were collected using a pre-structured checklist. The extracted data included patients’ demographic blood groups and risk factors, including history of inflammatory bowel disease or CRC. RESULTS: A total of 199 patients, aged 22 to 96 years (mean age: 61.6 ± 14.7 years), were included. The blood groups of 101 (50.8%), 59 (29.6%), 26 (13.1%), and 13 (6.5%) patients were O, A, B, and AB, respectively. Colon cancer was the most frequently reported cancer (155/199, 77.9%) across all blood groups and showed the highest frequency among patients with blood group O (74/155, 47.7%), without statistical significance (P = 0.111). CONCLUSION: Our study showed a statistically significant relationship between AB and non-O blood types and colon cancer compared to the O blood group. Elmer Press 2022-03 2022-03-12 /pmc/articles/PMC8993432/ /pubmed/35464604 http://dx.doi.org/10.14740/jocmr4691 Text en Copyright 2022, Al-Sawat et al. https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution Non-Commercial 4.0 International License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Al-Sawat, Abdullah
Alswat, Shrooq
Alosaimi, Rasha
Alharthi, Mohammed
Alsuwat, Mohammed
Alhasani, Kholoud
Alharthi, Walaa
Relationship Between ABO Blood Group and the Risk of Colorectal Cancer: A Retrospective Multicenter Study
title Relationship Between ABO Blood Group and the Risk of Colorectal Cancer: A Retrospective Multicenter Study
title_full Relationship Between ABO Blood Group and the Risk of Colorectal Cancer: A Retrospective Multicenter Study
title_fullStr Relationship Between ABO Blood Group and the Risk of Colorectal Cancer: A Retrospective Multicenter Study
title_full_unstemmed Relationship Between ABO Blood Group and the Risk of Colorectal Cancer: A Retrospective Multicenter Study
title_short Relationship Between ABO Blood Group and the Risk of Colorectal Cancer: A Retrospective Multicenter Study
title_sort relationship between abo blood group and the risk of colorectal cancer: a retrospective multicenter study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8993432/
https://www.ncbi.nlm.nih.gov/pubmed/35464604
http://dx.doi.org/10.14740/jocmr4691
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