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In‐hospital mortality in SARS‐CoV‐2 stratified by gamma‐glutamyl transferase levels
BACKGROUND: This study investigates in‐hospital mortality amongst patients with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and its relation to serum levels of gamma‐glutamyl transferase (GGT). METHODS: Patients were stratified according to serum levels of gamma‐glutamyl transferase...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8993645/ https://www.ncbi.nlm.nih.gov/pubmed/35261080 http://dx.doi.org/10.1002/jcla.24291 |
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author | Alroomi, Moudhi Rajan, Rajesh Alsaber, Ahmad Pan, Jiazhu Abdullah, Mohammed Abdelnaby, Hassan Aboelhassan, Wael AlNasrallah, Noor Al‐Bader, Bader Malhas, Haya Ramadhan, Maryam Hussein, Soumoud Alotaibi, Naser Al Saleh, Mohammad Zhanna, Kobalava D. Almutairi, Farah |
author_facet | Alroomi, Moudhi Rajan, Rajesh Alsaber, Ahmad Pan, Jiazhu Abdullah, Mohammed Abdelnaby, Hassan Aboelhassan, Wael AlNasrallah, Noor Al‐Bader, Bader Malhas, Haya Ramadhan, Maryam Hussein, Soumoud Alotaibi, Naser Al Saleh, Mohammad Zhanna, Kobalava D. Almutairi, Farah |
author_sort | Alroomi, Moudhi |
collection | PubMed |
description | BACKGROUND: This study investigates in‐hospital mortality amongst patients with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and its relation to serum levels of gamma‐glutamyl transferase (GGT). METHODS: Patients were stratified according to serum levels of gamma‐glutamyl transferase (GGT) (GGT<50 IU/L or GGT≥50 IU/L). RESULTS: A total of 802 participants were considered, amongst whom 486 had GGT<50 IU/L and a mean age of 48.1 (16.5) years, whilst 316 had GGT≥50 IU/L and a mean age of 53.8 (14.7) years. The chief sources of SARS‐CoV‐2 transmission were contact (366, 45.7%) and community (320, 40%). Most patients with GGT≥50 IU/L had either pneumonia (247, 78.2%) or acute respiratory distress syndrome (ARDS) (85, 26.9%), whilst those with GGT<50 IU/L had hypertension (141, 29%) or diabetes mellitus (DM) (147, 30.2%). Mortality was higher amongst patients with GGT≥50 IU/L (54, 17.1%) than amongst those with GGT<50 IU/L (29, 5.9%). More patients with GGT≥50 required high (83, 27.6%) or low (104, 34.6%) levels of oxygen, whereas most of those with GGT<50 had no requirement of oxygen (306, 71.2%). Multivariable logistic regression analysis indicated that GGT≥50 IU/L (odds ratio [OR]: 2.02, 95% confidence interval [CI]: 1.20–3.45, p=0.009), age (OR: 1.05, 95% CI: 1.03–1.07, p<0.001), hypertension (OR: 2.06, 95% CI: 1.19–3.63, p=0.011), methylprednisolone (OR: 2.96, 95% CI: 1.74–5.01, p<0.001) and fever (OR: 2.03, 95% CI: 1.15–3.68, p=0.016) were significant predictors of all‐cause cumulative mortality. A Cox proportional hazards regression model (B = −0.68, SE =0.24, HR =0.51, p = 0.004) showed that patients with GGT<50 IU/L had a 0.51‐times lower risk of all‐cause cumulative mortality than patients with GGT≥50 IU/L. CONCLUSION: Higher levels of serum GGT were found to be an independent predictor of in‐hospital mortality. |
format | Online Article Text |
id | pubmed-8993645 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89936452022-04-13 In‐hospital mortality in SARS‐CoV‐2 stratified by gamma‐glutamyl transferase levels Alroomi, Moudhi Rajan, Rajesh Alsaber, Ahmad Pan, Jiazhu Abdullah, Mohammed Abdelnaby, Hassan Aboelhassan, Wael AlNasrallah, Noor Al‐Bader, Bader Malhas, Haya Ramadhan, Maryam Hussein, Soumoud Alotaibi, Naser Al Saleh, Mohammad Zhanna, Kobalava D. Almutairi, Farah J Clin Lab Anal Research Articles BACKGROUND: This study investigates in‐hospital mortality amongst patients with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and its relation to serum levels of gamma‐glutamyl transferase (GGT). METHODS: Patients were stratified according to serum levels of gamma‐glutamyl transferase (GGT) (GGT<50 IU/L or GGT≥50 IU/L). RESULTS: A total of 802 participants were considered, amongst whom 486 had GGT<50 IU/L and a mean age of 48.1 (16.5) years, whilst 316 had GGT≥50 IU/L and a mean age of 53.8 (14.7) years. The chief sources of SARS‐CoV‐2 transmission were contact (366, 45.7%) and community (320, 40%). Most patients with GGT≥50 IU/L had either pneumonia (247, 78.2%) or acute respiratory distress syndrome (ARDS) (85, 26.9%), whilst those with GGT<50 IU/L had hypertension (141, 29%) or diabetes mellitus (DM) (147, 30.2%). Mortality was higher amongst patients with GGT≥50 IU/L (54, 17.1%) than amongst those with GGT<50 IU/L (29, 5.9%). More patients with GGT≥50 required high (83, 27.6%) or low (104, 34.6%) levels of oxygen, whereas most of those with GGT<50 had no requirement of oxygen (306, 71.2%). Multivariable logistic regression analysis indicated that GGT≥50 IU/L (odds ratio [OR]: 2.02, 95% confidence interval [CI]: 1.20–3.45, p=0.009), age (OR: 1.05, 95% CI: 1.03–1.07, p<0.001), hypertension (OR: 2.06, 95% CI: 1.19–3.63, p=0.011), methylprednisolone (OR: 2.96, 95% CI: 1.74–5.01, p<0.001) and fever (OR: 2.03, 95% CI: 1.15–3.68, p=0.016) were significant predictors of all‐cause cumulative mortality. A Cox proportional hazards regression model (B = −0.68, SE =0.24, HR =0.51, p = 0.004) showed that patients with GGT<50 IU/L had a 0.51‐times lower risk of all‐cause cumulative mortality than patients with GGT≥50 IU/L. CONCLUSION: Higher levels of serum GGT were found to be an independent predictor of in‐hospital mortality. John Wiley and Sons Inc. 2022-03-09 /pmc/articles/PMC8993645/ /pubmed/35261080 http://dx.doi.org/10.1002/jcla.24291 Text en © 2022 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Research Articles Alroomi, Moudhi Rajan, Rajesh Alsaber, Ahmad Pan, Jiazhu Abdullah, Mohammed Abdelnaby, Hassan Aboelhassan, Wael AlNasrallah, Noor Al‐Bader, Bader Malhas, Haya Ramadhan, Maryam Hussein, Soumoud Alotaibi, Naser Al Saleh, Mohammad Zhanna, Kobalava D. Almutairi, Farah In‐hospital mortality in SARS‐CoV‐2 stratified by gamma‐glutamyl transferase levels |
title | In‐hospital mortality in SARS‐CoV‐2 stratified by gamma‐glutamyl transferase levels |
title_full | In‐hospital mortality in SARS‐CoV‐2 stratified by gamma‐glutamyl transferase levels |
title_fullStr | In‐hospital mortality in SARS‐CoV‐2 stratified by gamma‐glutamyl transferase levels |
title_full_unstemmed | In‐hospital mortality in SARS‐CoV‐2 stratified by gamma‐glutamyl transferase levels |
title_short | In‐hospital mortality in SARS‐CoV‐2 stratified by gamma‐glutamyl transferase levels |
title_sort | in‐hospital mortality in sars‐cov‐2 stratified by gamma‐glutamyl transferase levels |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8993645/ https://www.ncbi.nlm.nih.gov/pubmed/35261080 http://dx.doi.org/10.1002/jcla.24291 |
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