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25-Hydroxyvitamin D reference percentiles and the role of their determinants among European children and adolescents
BACKGROUND/OBJECTIVES: To provide age- and sex-specific percentile curves of serum 25-hydroxyvitamin D (25(OH)D) by determinants from 3-<15 year-old European children, and to analyse how modifiable determinants influence 25(OH)D. SUBJECTS/METHODS: Serum samples were collected from children of eig...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8993686/ https://www.ncbi.nlm.nih.gov/pubmed/34302130 http://dx.doi.org/10.1038/s41430-021-00985-4 |
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author | Wolters, Maike Intemann, Timm Russo, Paola Moreno, Luis A. Molnár, Dénes Veidebaum, Toomas Tornaritis, Michael De Henauw, Stefaan Eiben, Gabriele Ahrens, Wolfgang Floegel, Anna |
author_facet | Wolters, Maike Intemann, Timm Russo, Paola Moreno, Luis A. Molnár, Dénes Veidebaum, Toomas Tornaritis, Michael De Henauw, Stefaan Eiben, Gabriele Ahrens, Wolfgang Floegel, Anna |
author_sort | Wolters, Maike |
collection | PubMed |
description | BACKGROUND/OBJECTIVES: To provide age- and sex-specific percentile curves of serum 25-hydroxyvitamin D (25(OH)D) by determinants from 3-<15 year-old European children, and to analyse how modifiable determinants influence 25(OH)D. SUBJECTS/METHODS: Serum samples were collected from children of eight European countries participating in the multicenter IDEFICS/I.Family cohort studies. Serum 25(OH)D concentrations were analysed in a central lab by a chemiluminescence assay and the values from 2171 children (N = 3606 measurements) were used to estimate percentile curves using the generalized additive model for location, scale and shape. The association of 25(OH)D with time spent outdoors was investigated considering sex, age, country, parental education, BMI z score, UV radiation, and dietary vitamin D in regressions models. RESULTS: The age- and sex-specific 5th and 95th percentiles of 25(OH)D ranged from 16.5 to 73.3 and 20.8 to 79.3 nmol/l in girls and boys, respectively. A total of 63% had deficient (<50 nmol/l), 33% insufficient (50-<75 nmol/l) and 3% sufficient (≥75 nmol/l) levels. 25(OH)D increased with increasing UV radiation, time spent outdoors, and vitamin D intake and slightly decreased with increasing BMI z score and age. The odds ratio (OR) for a non-deficient 25(OH)D status (reference category: deficient status) by one additional hour spent outdoors was 1.21, 95% CI [1.12–1.31], i.e., children who spent one more hour per day outdoors than other children had a 21% higher chance of a non-deficient than a deficient status. CONCLUSION: A majority of children suffer from deficient 25(OH)D. UV radiation, outdoor time, and dietary vitamin D are important determinants of 25(OH)D. |
format | Online Article Text |
id | pubmed-8993686 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-89936862022-04-22 25-Hydroxyvitamin D reference percentiles and the role of their determinants among European children and adolescents Wolters, Maike Intemann, Timm Russo, Paola Moreno, Luis A. Molnár, Dénes Veidebaum, Toomas Tornaritis, Michael De Henauw, Stefaan Eiben, Gabriele Ahrens, Wolfgang Floegel, Anna Eur J Clin Nutr Article BACKGROUND/OBJECTIVES: To provide age- and sex-specific percentile curves of serum 25-hydroxyvitamin D (25(OH)D) by determinants from 3-<15 year-old European children, and to analyse how modifiable determinants influence 25(OH)D. SUBJECTS/METHODS: Serum samples were collected from children of eight European countries participating in the multicenter IDEFICS/I.Family cohort studies. Serum 25(OH)D concentrations were analysed in a central lab by a chemiluminescence assay and the values from 2171 children (N = 3606 measurements) were used to estimate percentile curves using the generalized additive model for location, scale and shape. The association of 25(OH)D with time spent outdoors was investigated considering sex, age, country, parental education, BMI z score, UV radiation, and dietary vitamin D in regressions models. RESULTS: The age- and sex-specific 5th and 95th percentiles of 25(OH)D ranged from 16.5 to 73.3 and 20.8 to 79.3 nmol/l in girls and boys, respectively. A total of 63% had deficient (<50 nmol/l), 33% insufficient (50-<75 nmol/l) and 3% sufficient (≥75 nmol/l) levels. 25(OH)D increased with increasing UV radiation, time spent outdoors, and vitamin D intake and slightly decreased with increasing BMI z score and age. The odds ratio (OR) for a non-deficient 25(OH)D status (reference category: deficient status) by one additional hour spent outdoors was 1.21, 95% CI [1.12–1.31], i.e., children who spent one more hour per day outdoors than other children had a 21% higher chance of a non-deficient than a deficient status. CONCLUSION: A majority of children suffer from deficient 25(OH)D. UV radiation, outdoor time, and dietary vitamin D are important determinants of 25(OH)D. Nature Publishing Group UK 2021-07-23 2022 /pmc/articles/PMC8993686/ /pubmed/34302130 http://dx.doi.org/10.1038/s41430-021-00985-4 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Wolters, Maike Intemann, Timm Russo, Paola Moreno, Luis A. Molnár, Dénes Veidebaum, Toomas Tornaritis, Michael De Henauw, Stefaan Eiben, Gabriele Ahrens, Wolfgang Floegel, Anna 25-Hydroxyvitamin D reference percentiles and the role of their determinants among European children and adolescents |
title | 25-Hydroxyvitamin D reference percentiles and the role of their determinants among European children and adolescents |
title_full | 25-Hydroxyvitamin D reference percentiles and the role of their determinants among European children and adolescents |
title_fullStr | 25-Hydroxyvitamin D reference percentiles and the role of their determinants among European children and adolescents |
title_full_unstemmed | 25-Hydroxyvitamin D reference percentiles and the role of their determinants among European children and adolescents |
title_short | 25-Hydroxyvitamin D reference percentiles and the role of their determinants among European children and adolescents |
title_sort | 25-hydroxyvitamin d reference percentiles and the role of their determinants among european children and adolescents |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8993686/ https://www.ncbi.nlm.nih.gov/pubmed/34302130 http://dx.doi.org/10.1038/s41430-021-00985-4 |
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